Our organism is daily exposed to a massive amount of xenobiotics, heavy metals, pesticides, and food preservatives. In this scenario, the health of the intestinal microbiota represents our first true biological line of defense. Symbiotic bacteria not only neutralize and eliminate toxins through their own life cycle, but also constantly stimulate lymphocytes (T-regulatory), pillars of immune tolerance against allergies, food sensitivities and autoimmune inflammation.
However, common insults such as improper antibiotic therapies (particularly with macrolides, capable of eradicating up to 80% of bacterial biodiversity) or the proliferation of dysbiotic Gram-negative strains determine the release of lipopolysaccharide (LPS). This endotoxin undermines the integrity of the enteric mucosa, triggering Leaky Gut Syndrome (intestinal permeability syndrome). The resulting systemic inflammation sends alarm signals to the hypothalamus which, perceiving a threat to survival, responds by activating a precautionary block of the metabolic axes (thyroid, adrenal, gonads), inducing a slowdown of energy consumption and the consequent fattening.
To break this vicious circle, the therapeutic approach of Signal Medicine involves the synergistic use of pure phytocomplexes and alkalizing minerals aimed at healing the intestinal environment, supporting elimination pathways, and restoring urothelial and enteric barriers.
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Recommended Dosage Schedule
To ensure 24-hour coverage and optimize bio-absorption and cellular synergy processes, the protocol involves the combined intake of the remedies during the two main meals of the day:
· During Lunch:
o 2 capsules of Bioalcalino M&C
o 1 capsule of Cistaloe
· During Dinner:
o 2 capsules of Bioalcalino M&C
o 1 capsule of Cistaloe
Intake notes: Swallow the capsules whole with a large glass of water. Both products are enclosed in the purest plant-based capsules, completely free of preservatives, colorants, added chemicals, or unnecessary additives, making them ideal for strictly vegan and vegetarian diets.
Scientific Rationale and Chronobiology of the Dosage
The split dosage and simultaneous intake of Bioalcalino M&C and Cistaloe at lunch and dinner respond to precise pharmacokinetic and synergistic needs:
1. Bioalcalino M&C (4 capsules total: 2 at lunch and 2 at dinner)
· Buffering of tissue and inflammatory acidosis: Chronic inflammation induced by the passage of lipopolysaccharides (LPS) and toxins into the blood generates a state of latent metabolic acidosis. The split intake of alkalizing mineral salts at lunch and dinner acts as a continuous buffering system, restoring the correct pH of the extracellular matrix and supporting the activity of detoxifying enzymes.
· Regulation of motility and enteric barrier: Providing mineral and organic support elements during main meals allows to aid digestion and reduce the chemical stress induced on the intestinal mucosa by aggressive substances present in foods (preservatives, pesticides).
· Deactivation of hypothalamic alarm signals: By stabilizing the acid-base balance and reducing metabolic endotoxemia 24/7, the threat signals directed to the hypothalamus are reduced, promoting the unblocking of consumption and the restoration of normal energy expenditure.
2. Cistaloe (2 capsules total: 1 at lunch and 1 at dinner)
· Soothing and healing "bandage" effect on mucosae: The active principles of Cistaloe, particularly the polysaccharides of Aloe, act by forming a protective hydrogel on the inflamed and hyper-permeable walls of the intestine (Leaky Gut) and the lower urinary tract. The split intake at midday and evening ensures that this biological shield is constantly present during digestive phases and during nocturnal stasis.
· Prevention of bacterial adhesion and immune protection: Evening administration is crucial: it ensures that the phytocompounds remain in contact with the urothelium and mucosae during the night hours, preventing colonization by opportunistic pathogens that exploit moments of stasis to proliferate and alter local immune defenses.
PLEASE NOTE: The information present in the product sheets on this site is exclusively for informative and educational purposes and does not represent a medical opinion. The published contents are not intended to replace the relationship with the doctor nor any medical indications, diagnoses, or prescriptions. The reported information describes the ingredients and characteristics of food supplements, designed as support for the balance and well-being of the organism within a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or pathological conditions.
Bibliographic References and Clinical Literature Sources
1. Kozyrskyj, A. L. et al. (2007). Increased risk of childhood asthma after antibiotic use in low-risk children. Chest, 131(6), 1753-1759.
2. Hviid, A. et al. (2011). Antibiotic use and inflammatory bowel diseases in childhood. American Journal of Epidemiology, 174(5), 575-582.
3. Mårild, K. et al. (2013). Antibiotic exposure and the risk of celiac disease: a nationwide case-control study. BMC Gastroenterology, 13(1), 109.
4. Cani, P. D. et al. (2008). Changes in gut microbiota control metabolic endotoxemia-induced inflammation, high-fat diet-induced obesity and diabetes trends. Gut, 57(6), 778-787.
5. Blaser, M. J. (2014). Missing Microbes: How the Overuse of Antibiotics Is Fueling Our Modern Plagues. Henry Holt and Company.
6. Vitetta, L. et al. (2013). The gastrointestinal microbiome and musculoskeletal diseases: a role for T-regulatory cells. Inflammation, 36(3), 515-524.
