1. Why address chronic low-grade inflammation
Chronic low-grade inflammation (inflammaging) is often an asymptomatic but biologically active condition, characterized by a persistent increase in pro-inflammatory mediators (e.g., TNF-α, IL-6, CRP).
Over time, it can contribute to the development of:
- cardiovascular diseases
- metabolic diseases (insulin resistance, obesity)
- neurodegenerative diseases
- autoimmune diseases
Unlike acute inflammation (which is beneficial and physiological), chronic inflammation does not resolve spontaneously and requires a systemic modulation approach.
LUNAE combines three components with complementary mechanisms, consistent with the pathophysiology of chronic inflammation
The dosage of 1 tablet per day represents:
- a physiological maintenance dose, suitable for individuals:
- with subclinical inflammation
- experiencing chronic stress or an unhealthy lifestyle
- a safe and well-tolerated approach
- a functional prevention strategy that is not pharmacological
At the doses included:
- inflammatory mediators are gradually modulated
- the risk of overdose or adverse effects is avoided
If needed (during an acute phase or when symptoms are more pronounced), the dose may be increased to 2 tablets/day on the recommendation of a healthcare professional.
2. Rationale for supplementation: why LUNAE
LUNAE combines three components with complementary mechanisms, consistent with the pathophysiology of chronic inflammation:
Bromelain
- Proteolytic enzymatic action
- Reduction of edema and inflammatory mediators
- Modulation of the immune response
Evidence:
- Reduction in post-surgical pain and edema (de Souza et al., 2019)
- Systemic anti-inflammatory activity (Varilla et al., 2021)
Boswellia serrata (boswellic acids, AKBA)
- Selective inhibition of 5-LOX → ↓ leukotrienes
- NF-κB modulation
- Protection of joint and intestinal tissues
Evidence:
- Improvement in osteoarthritis symptoms (Kimmatkar et al., 2003)
- Activity in inflammatory bowel disease (Gupta et al., 1997)
Tetrahydrocurcuminoids (THC)
- High antioxidant activity
- Greater bioavailability than curcumin
- Cellular protection and modulation of oxidative stress
Evidence (curcuminoids):
- Reduction in CRP, TNF-α, IL-6 (Sahebkar et al., 2016)
- Benefits in osteoarthritis and metabolic syndrome (Panahi et al., 2016)
3. Biological synergy
The combination in LUNAE acts at multiple levels:
- Inflammation → Boswellia + curcuminoids
- Edema and microcirculation → Bromelain
- Oxidative stress → Tetrahydrocurcuminoids
- Immunomodulation → combined action
This approach is consistent with the multifactorial nature of silent chronic inflammation.
4. Why 1 tablet per day
The dosage of 1 tablet per day represents:
- a physiological maintenance dose, useful in individuals:
- with subclinical inflammation
- with chronic stress or an suboptimal lifestyle
- a safe and well-tolerated approach
- a functional prevention strategy, non-pharmacological
At the doses provided:
- a gradual modulation of inflammatory mediators is achieved
- the risk of overdose or adverse effects is avoided
If necessary (acute phase or more evident symptoms), the dose can be increased to 2 tablets/day according to professional guidance.
5. Who it is recommended for
LUNAE can be useful as nutritional support in:
- chronic fatigue and latent inflammation
- mild muscle or joint pain
- functional gastrointestinal disorders
- individuals with high oxidative stress
- prevention of inflammaging
6. Safety and warnings (for the patient)
- Does not replace a balanced diet
- Avoid in case of:
- gallstones (turmeric)
- pineapple allergy (bromelain)
- Caution if taking:
- anticoagulants
- chemotherapy drugs
- During pregnancy: avoid (Boswellia)
“One tablet a day helps your body control hidden inflammatory processes, supporting balance, energy, and well-being over time.”
PLEASE NOTE: The information provided in the product sheets on this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace the doctor-patient relationship or any medical advice, diagnosis, or prescription. The information provided describes the ingredients and characteristics of the food supplements, which are intended to support the body's balance and well-being as part of a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.
Essential bibliographic references
- de Souza GM et al. Phytother Res. 2019
- Varilla V et al. Evid Based Complement Alternat Med. 2021
- Sahebkar A et al. Pharmacol Res. 2016
- Panahi Y et al. J Diet Suppl. 2016
- Kimmatkar N et al. Phytomedicine. 2003
- Gupta I et al. Eur J Med Res. 1997
- Aggarwal BB et al. Trends Pharmacol Sci. 2009
