When a local symptom stems from a systemic imbalance
Modern knowledge in Psycho-Neuro-Endocrino-Immunology (PNEI) shows that many chronic inflammatory conditions cannot be interpreted solely as problems of a single organ.
An increasing number of studies highlight that low-grade systemic inflammation, intestinal dysbiosis, and dysregulation of the stress response are common factors in numerous disorders affecting the urinary tract, intestine, skin, nervous system, and immune system.
The intestine, through the microbiota and the intestinal barrier, plays a fundamental role in regulating inflammation and communicating with the entire PNEI axis.
When chronic stress, inadequate nutrition, dysbiosis, or persistent inflammatory events alter this balance, local symptoms may appear, representing the peripheral expression of a broader imbalance.
In these cases, the therapeutic goal is not only to control the symptom, but to promote the restoration of overall biological balance.
PRODUCT_ITEM
Recommended nutraceutical protocol
Cistaloe®
- 1 capsule at lunch
- 1 capsule at dinner
Lunae®
- 1 tablet at lunch
- 1 tablet at dinner
The combination of Cistaloe and Lunae was designed to simultaneously support:
- the well-being of the urinary tract;
- physiological control of inflammation;
- intestinal balance;
- protection from oxidative stress;
- the modulation of biological responses associated with chronic stress.
Cistaloe®: urinary and intestinal ecosystem support
Cistaloe was created to support the physiological well-being of the urinary tract through the synergistic action of plant extracts, antioxidant nutrients, and substances with protective effects on the mucous membranes.
American Cranberry (Cranberry)
Cranberry is one of the most studied ingredients for urinary tract support.
The proanthocyanidins (PACs) found in the fruit:
- reduce the adhesion of certain uropathogenic bacteria to the urothelial walls;
- promote the maintenance of urinary microbial balance;
- support the physiological protection of the mucous membranes.
Numerous clinical studies and meta-analyses have confirmed its role in reducing the frequency of recurrent urinary tract infections in predisposed individuals.
Aloe Arborescens
Aloe Arborescens is traditionally used to:
- support the integrity of the mucous membranes;
- promote intestinal balance;
- contribute to the physiological antioxidant response.
The intestine is one of the main regulators of systemic inflammation and immune function; maintaining its integrity can have beneficial effects on the entire body.
Vitamin C
Vitamin C contributes:
- to the normal function of the immune system;
- to protection from oxidative stress;
- to the synthesis of collagen necessary for the well-being of the mucous membranes.
Zinc
Zinc intervenes in numerous biological processes:
- immune regulation;
- integrity of epithelial barriers;
- control of oxidative stress;
- tissue repair.
Lunae®: physiological modulation of inflammation
While Cistaloe primarily acts on the biological terrain and the well-being of the mucous membranes, Lunae intervenes in the mechanisms that sustain low-grade chronic inflammation.
The formulation contains:
- Boswellia serrata;
- Bromelain;
- Tetrahydrocurcuminoids.
Boswellia serrata
Boswellic acids act on the 5-lipoxygenase (5-LOX) pathway, which is involved in the production of pro-inflammatory leukotrienes.
Numerous clinical publications have documented:
- reduction of inflammatory mediators;
- improvement of tissue comfort;
- support of the physiological processes of inflammation resolution.
Bromelain
Bromelain, extracted from pineapple, promotes:
- tissue drainage;
- physiological resorption of edema;
- regulation of inflammatory responses.
Clinical studies suggest benefits in the management of chronic inflammatory and congestive processes.
Tetrahydrocurcuminoids
Tetrahydrocurcuminoids are highly bioavailable metabolites of turmeric.
Their properties include:
- antioxidant activity;
- cellular protection;
- modulation of inflammatory cytokines;
- support of endothelial function.
The connection with the PNEI axis
The PNEI teaches us that:
- inflammation;
- chronic stress;
- microbiota;
- immune system;
- nervous system
are not separate compartments.
A persistent imbalance can fuel a vicious cycle characterized by:
- increased cortisol;
- altered intestinal permeability;
- dysbiosis;
- increased inflammatory cytokines;
- increased peripheral tissue vulnerability.
The combination of Cistaloe and Lunae fits into this context as a nutraceutical support aimed at promoting the recovery of general biological balance.
The rationale of the Cistaloe® + Lunae® combination
The combination allows action on different levels simultaneously:
Mucosal well-being
- Aloe Arborescens
- Cranberry
- Vitamin C
- Zinc
Immune balance
- Vitamin C
- Zinc
- plant phytocomplex
Physiological control of inflammation
- Boswellia
- Bromelain
- Tetrahydrocurcuminoids
Antioxidant protection
- Vitamin C
- Curcuminoids
- Cranberry polyphenols
Gut-immunity axis support
- Aloe Arborescens
- Indirect modulation of systemic inflammation
Conclusions
Low-grade chronic inflammation is one of the main common denominators of modern diseases and profoundly involves the PNEI axis.
Support of the gut, mucosae, microbiota and physiological processes of inflammation regulation can help break the vicious cycles that sustain chronic discomfort.
The combination of Cistaloe® and Lunae® represents an integrated approach aimed at supporting urinary, intestinal and systemic well-being, promoting the recovery of the body's biological balance.
Bibliography
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Dinan TG, Cryan JF. Gut microbiota and mental health. World Psychiatry. 2020;19(1):111-112.
Mayer EA. Gut feelings: the biology of gut-brain communication. Nat Rev Neurosci. 2011;12:453-466.
Fu Z et al. Cranberry reduces the risk of urinary tract infection recurrence: systematic review and meta-analysis. Journal of Nutrition. 2017;147(12):2282-2288.
Ammon HP. Boswellia serrata and inflammatory diseases. Planta Medica. 2006;72:1100-1116.
Pavan R et al. Properties and therapeutic application of bromelain. Biotechnology Research International. 2012;976203.
Hewlings SJ, Kalman DS. Curcumin: a review of its effects on human health. Foods. 2017;6(10):92.
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