An integrated approach to men’s health
Arterial hypertension and prostate and urinary tract disorders belong to different physiological systems, but share several important biological and behavioral determinants: age, sedentary lifestyle, being overweight, an unbalanced diet, oxidative stress, and metabolic alterations can all contribute over time to impaired cardiovascular and metabolic health.
As discussed in the article “Prevention and treatment of arterial hypertension with herbal medicine and phytotherapy”, cardiovascular prevention cannot be entrusted to a single ingredient but must be based on a combination of interventions: a balanced diet, physical activity, weight management, reduced sodium intake, smoking cessation, moderate alcohol consumption, stress management, and, when indicated, pharmacological therapy. Some medicinal plants may provide complementary support, but they are not a substitute for medicines prescribed by a doctor.
In particular, Olea europaea L., found in Fisiodyn, is one of the plants for which compelling clinical data are available on blood pressure control. A multicenter, randomized, double-blind, placebo-controlled trial published in 2025 in the Journal of Hypertension involved 621 people with hypertension already being treated with medication. After 12 weeks, olive leaf extract resulted in a significant reduction in 24-hour systolic blood pressure, along with improvements in several metabolic parameters. A 2025 meta-analysis also found a reduction in systolic blood pressure in the available studies, while highlighting the heterogeneity of the protocols and the need for further studies.
However, it is important not to confuse these data with the therapeutic efficacy of the entire Fisiodyn product on hypertension: the clinical studies cited used specific olive leaf extracts, often at different dosages and standardization levels than those found in the supplement. Scientific data should therefore be used as a biological rationale for the role of oleuropein, not as clinical evidence of Fisiodyn’s efficacy in treating hypertension.
Moltitudine describes Fisiodyn as an integrated system for musculoskeletal longevity, developed around the combination of oleuropein, polydatin, vitamin D3, and vitamin K2.
At the same time, Prostaloe was designed with a multi-target strategy aimed at physiologically supporting the prostate and urinary tract, combining plant extracts and micronutrients with different antioxidant and physiological activities.
This guide therefore proposes a nutritional rationale for combining the two products, without attributing therapeutic properties to them.
The entire approach is also consistent with the Moltitudo philosophy, which develops supplements with vegan formulas and highly pure selected raw materials. The Moltitudo website presents the project as being focused on vegan formulas, selected active ingredients, the absence of unnecessary industrial excipients, and small-batch artisanal production.
PRODUCT_ARTICLE
Recommended dosage
Morning
1 Fisiodyn capsule, preferably during breakfast.
Lunch
2 Prostaloe capsules, during the meal.
Evening
1 Fisiodyn capsule, during dinner.
2 Prostaloe capsules, during dinner.
The total daily dose is therefore:
- Fisiodyn: 2 capsules per day
- Prostaloe: 4 capsules per day
For Prostaloe, the daily dose of 4 capsules corresponds to the quantity for which the formulation was defined: 1,800 mg of total ingredients.
Dividing Prostaloe between lunch and dinner also allows the intake of a formulation particularly rich in plant extracts and polyphenols to be spread throughout the day.
The rationale for Fisiodyn
Fisiodyn contains, per daily dose of 2 capsules, 286 mg of Olea europaea leaf extract standardized to 70% oleuropein, equivalent to 200 mg of oleuropein, 51 mg of polydatin, 24 µg of vitamin K2 (MK-7), and 25 µg of vitamin D3.
The formulation is therefore built around four complementary components.
Oleuropein: the bridge between oxidative stress and cardiovascular function
Oleuropein is one of the main secoiridoids in olive leaves. Its biological activity has been studied in relation to oxidative stress, endothelial function, lipid metabolism, and the regulation of certain mechanisms involved in the inflammatory response.
Interest in oleuropein is particularly relevant in the context of cardiovascular prevention.
A randomized, double-blind study conducted on subjects with grade 1 hypertension had already compared an olive leaf extract with captopril, highlighting a favorable effect of the extract on blood pressure levels.
More recently, the 2025 trial involving 621 patients confirmed that a specific olive leaf extract can contribute to reducing blood pressure in hypertensive people.
A further 2026 study observed favorable effects on blood pressure and certain cardiometabolic parameters with a combination of olive leaf extract and potassium, although the formulation used in the study does not match Fisiodyn and therefore the results cannot be directly transferred to the product.
These data make oleuropein a particularly interesting ingredient within a nutritional strategy aimed at protection from oxidative stress and the maintenance of normal cardiovascular function.
Polydatin: redox modulation and cellular protection
Polydatin is a resveratrol glucoside found, among other plant sources, in the root of Fallopia japonica.
At the experimental level, it has been studied for its ability to modulate cellular pathways involved in oxidative stress, inflammation, and cellular metabolism.
In the case of Fisiodyn, polydatin is combined with oleuropein according to a multi-target approach: the goal is not to seek a single effect, but to provide different plant molecules capable of interacting with biological processes related to tissue aging.
However, it is important to clarify that human clinical evidence for polydatin as a single ingredient is much less robust than that available for oleuropein.
Vitamin D3: muscle function and bone metabolism
Fisiodyn provides 25 µg of vitamin D3, equivalent to 500% of the NRV.
Vitamin D contributes to the maintenance of normal muscle function and the maintenance of normal bones. Its role becomes particularly important with advancing age, when the preservation of muscle mass and function becomes one of the central elements of musculoskeletal longevity.
Vitamin K2: physiological bone metabolism
Vitamin K contributes to the maintenance of normal bones.
The MK-7 form found in Fisiodyn belongs to the vitamin K2 forms that are most studied for their bioavailability and their involvement in the vitamin K-dependent protein system.
The combination of vitamin D and vitamin K within Fisiodyn is therefore consistent with a nutritional approach aimed at maintaining the normal homeostasis of bone tissue.
The rationale for Prostaloe
Prostaloe uses a very different and complementary strategy.
The daily dose of four capsules provides:
Turmeric: 300 mg of extract standardized to 95% curcuminoids, equivalent to 285 mg of curcuminoids.
Pomegranate: 300 mg of extract standardized to 20% ellagic acid, equivalent to 60 mg.
Serenoa repens: 300 mg of extract standardized to 30% fatty acids, equivalent to 90 mg.
Green tea: 200 mg of extract standardized to 95% polyphenols, equivalent to 190 mg of polyphenols, of which 105 mg are catechins and 60 mg are EGCG.
Broccoli: 200 mg of extract standardized to 0.3-0.5% sulforaphane, equivalent to 1 mg of sulforaphane.
Garlic: 200 mg of extract standardized to 1% alliin, equivalent to 2 mg of alliin.
Quercetin: 100 mg of substance standardized to 98%, equivalent to 98 mg.
Pumpkin seeds: 100 mg of extract.
Hawthorn: 71 mg of extract standardized to 70% ascorbic acid, equivalent to 50 mg of vitamin C.
Vitamin E: 9 mg, equivalent to 75% of the NRV.
Selenium: 55 µg, equivalent to 100% of the NRV.
The formulation therefore combines three areas of interest: physiological prostate-urinary support, protection from oxidative stress, and modulation of cellular processes involved in tissue homeostasis.
Serenoa repens and prostate function
Serenoa repens represents the component most directly linked to prostate physiology.
Its fruits are rich in a lipid fraction containing fatty acids and phytosterols. Serenoa lipid extract has been studied mainly in the context of lower urinary tract symptoms associated with benign prostatic hyperplasia.
The biological rationale includes interaction with androgen metabolism and pathways involved in the proliferation and inflammation of prostatic tissue.
However, it is important to maintain a proper perspective: clinical studies on Serenoa have produced results that are not always consistent, and efficacy may depend heavily on the type of extract, standardization, and dose.
For this reason, Prostaloe should be presented as nutritional support for normal prostate and urinary function, not as a treatment for benign prostatic hyperplasia.
Turmeric and curcuminoids
Turmeric provides 285 mg of highly standardized curcuminoids.
Curcumin has been studied for its ability to modulate numerous intracellular pathways, including NF-κB, COX-2, and other mediators involved in the inflammatory response and oxidative stress.
In the field of urology and prostate health, the rationale derives mainly from experimental data and certain clinical studies on specific conditions. It is therefore not correct to turn this evidence into a therapeutic indication for the prostate.
Its presence in Prostaloe serves mainly to contribute to the antioxidant multi-target strategy and the physiological modulation of the cellular response.
Pomegranate and ellagic acid
Pomegranate is a source of polyphenols, including ellagitannins and ellagic acid derivatives.
Pomegranate polyphenol metabolism produces bioactive molecules that have been studied for their antioxidant properties and their possible interaction with cellular processes involved in inflammation and tissue metabolism.
Pomegranate has also been studied in the context of the prostate. A phase II clinical trial evaluated the consumption of pomegranate juice in men with progressively increasing PSA, observing a prolongation of the PSA doubling time; however, this is an exploratory study and does not demonstrate a therapeutic effect on prostate cancer.
These data are therefore useful for understanding the biological rationale, but do not authorize the use of Prostaloe for the prevention or treatment of prostate cancer.
Green tea, catechins and EGCG
Green tea provides 60 mg of EGCG.
Green tea catechins are among the most studied polyphenols for their ability to interact with oxidative stress, cell signaling and numerous enzymatic systems.
EGCG has also been extensively studied in relation to prostate biology, but clinical evidence is still insufficient to attribute a therapeutic role to it.
Its inclusion in Prostaloe therefore contributes to the multi-polyphenol model of the formulation.
Broccoli and sulforaphane
Sulforaphane is an isothiocyanate derived from the glucosinolates of Brassicaceae.
Its main biological interest derives from the ability to activate Nrf2, a central transcription factor in the cellular response to oxidative stress. The activation of Nrf2 promotes the expression of numerous cytoprotective enzymes and endogenous systems involved in the management of redox stress.
Sulforaphane therefore represents, within Prostaloe, the component aimed not only at the supply of direct antioxidants, but also at the stimulation of endogenous cellular defense systems.
Quercetin
Quercetin is a flavonoid widely studied for its antioxidant activity and its ability to modulate various cell signaling pathways.
Its role in the formulation completes that of curcuminoids, green tea polyphenols and ellagic acid, creating a matrix of molecules belonging to different chemical classes.
Garlic
Garlic provides 2 mg of alliin.
As also explored in the previous Moltitudo article on hypertension, garlic has been studied in relation to cardiovascular function and blood pressure. Its organosulfur molecules can interact with the production of nitric oxide and other systems involved in the regulation of vascular tone.
In Prostaloe, however, garlic should not be interpreted as a primary antihypertensive ingredient, but as an additional component of the nutritional strategy based on sulfur compounds and antioxidants.
Pumpkin seeds
Pumpkin seeds belong to the nutritional and phytotherapeutic tradition linked to the well-being of the urinary tract.
Clinical and observational studies have explored their possible role in improving urinary symptoms, particularly in adult men with lower urinary tract disorders.
Their presence completes that of Serenoa, without completely overlapping the biological mechanisms.
Vitamin C, vitamin E and selenium
The micronutrient part of the formulation contributes to the protection of cells from oxidative stress.
In fact, vitamin C, vitamin E and selenium participate in different physiological antioxidant systems.
In particular:
- vitamin C contributes to the protection of cells from oxidative stress;
- vitamin E contributes to the protection of cells from oxidative stress;
- selenium contributes to the protection of cells from oxidative stress and the normal function of the immune system.
These are authorized nutritional claims, to be distinguished from the possible pharmacological properties attributed to individual extracts in experimental studies.
Why combine Fisiodyn and Prostaloe?
The association does not arise from the idea that two supplements should simply add up, but from the different physiological destination of the two formulations.
Fisiodyn concentrates its strategy on:
Olea europaea + polydatin + vitamin D3 + vitamin K2
with an orientation towards musculoskeletal longevity, bone metabolism, muscle function and protection from oxidative stress. The Moltitudo site indeed identifies Fisiodyn as an integrated system for muscle, bone and musculoskeletal longevity.
Prostaloe concentrates its strategy on:
Serenoa + curcuminoids + pomegranate + green tea + broccoli + garlic + quercetin + pumpkin seeds + vitamin C + vitamin E + selenium
with a multi-target approach aimed at the support of physiological prostate and urinary functionality and protection from oxidative stress.
The association therefore allows to build a broader nutritional program, in which the first product is oriented mainly towards the musculoskeletal and metabolic-vascular component and the second towards the prostate and urinary component.
This distinction is also important from a communication point of view: it is not a therapy for hypertension, prostatic hyperplasia, prostatitis, prostate cancer, osteoporosis or other pathologies, but a nutritional integration strategy intended to support the normal physiological functions of the organism.
Why distribute them during the day?
The proposed choice of taking Fisiodyn in the morning and evening and Prostaloe at lunch and dinner allows to distribute the supply of ingredients throughout the day.
Taking during meals is also consistent with the presence of numerous plant substances and fat-soluble vitamins.
The division of Fisiodyn into one capsule in the morning and one in the evening maintains the daily dose provided by the formulation, while the division of Prostaloe into two capsules at lunch and two at dinner avoids concentrating all four capsules in a single administration.
The dosage must however be that reported on the current product label and, in case of differences between this guide and the label, the label prevails.
A vegan strategy
A characteristic element of the Moltitudo approach is the attention towards vegan formulations.
The Moltitudo catalog indeed presents the project as oriented towards the development of vegan supplements and cosmetics and indicates among its principles the use of selected raw materials and the reduction of superfluous industrial excipients.
Fisiodyn also uses a capsule of plant origin, consistent with this approach.
The “vegan” characterization must however be referred to the product in its actually certified/marketed formulation and production: for regulatory or certification needs, the official documentation of the batch and the manufacturer must always be verified.
When is it appropriate to talk to the doctor
Integration must not replace a clinical evaluation when persistent urinary symptoms, difficulty urinating, blood in the urine or semen, pelvic pain, fever, urinary retention, significant PSA alterations or other new symptoms are present.
Likewise, those who present diagnosed hypertension should not autonomously change the pharmacological therapy based on the intake of Fisiodyn or other supplements.
Particular caution is necessary in case of therapy with anticoagulants or antiplatelet drugs, cardiovascular drugs, diabetes drugs, diuretics or other medicines that can interact with plant components.
The presence of vitamin K2 also makes the discussion with the doctor particularly important for people who take vitamin K antagonists, such as warfarin.
PLEASE NOTE
PLEASE NOTE: The information present in the product sheets of this site is exclusively for informative and educational purposes and does not represent a medical opinion. The published contents do not intend to replace the relationship with the doctor nor any medical indications, diagnoses or prescriptions. The reported information describes the ingredients and characteristics of food supplements, designed as support for the balance and well-being of the organism within a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat or alleviate diseases or pathological conditions.
References and further reading
Reference Moltitudo article on hypertension: Prevention and treatment of arterial hypertension with phytotherapy and gemmotherapy. The article explores the role of lifestyle and the main medicinal plants studied for blood pressure control, including olive, garlic, hibiscus, and hawthorn.
Moltitudo article on the prostate: Integrated phytotherapy in prostate and urinary tract issues: biological rationale, scientific evidence and proposed approach according to the Dr. Gabriele Mammana protocol. The article addresses prostate physiology, LUTS, IPB and the rationale of integrated phytotherapy.
Moltitudo – Fisiodyn: official Fisiodyn page
Moltitudo – Scientific blog: Moltitudo News
Essential scientific bibliography
- Lamti F, et al. Efficacy of olive leaf extracts in controlling blood pressure in hypertensive patients: a double-blind randomized clinical trial. Journal of Hypertension. 2025;43(11):1878-1884.
- Lachovicz R, Ferro-Lebres V, Almeida-de-Souza J, Pereira JA. Efficacy of Olive Leaf Extract in Improving Blood Pressure in Pre-Hypertensive and Hypertensive Individuals: A Systematic Review and Meta-Analysis. Phytotherapy Research. 2025.
- Fladerer-Grollitsch JP, et al. Effects of a combination of olive leaf extract and potassium on blood pressure in participants with mild to moderate hypertension: A double blind, randomized, placebo-controlled trial. Phytomedicine. 2026;155:158138.
- Lockyer S, et al. Impact of phenolic-rich olive leaf extract on blood pressure, plasma lipids and inflammatory markers: a randomised controlled trial. European Journal of Nutrition. 2017.
- Conquer JA, et al. Olive (Olea europaea) leaf extract effective in patients with stage-1 hypertension: comparison with Captopril. Phytotherapy Research. 2011.
- Bent S, Kane C, Shinohara K, et al. Saw palmetto for benign prostatic hyperplasia. New England Journal of Medicine. 2006;354:557-566.
- Vahlensieck W, et al. Effects of pumpkin seed in men with lower urinary tract symptoms. Urologia Internationalis. 2015;94:286-295.
- Pantuck AJ, et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiotherapy for prostate cancer. Clinical Cancer Research. 2006;12:4018-4026.
- Shafabakhsh R, et al. Curcumin: A review of its effects on human health. Foods. 2017;6:92.
- Henning SM, et al. Green tea catechins and prostate cancer prevention. Cancer Prevention Research. 2011;4:393-400.
- Fahey JW, et al. Sulforaphane bioavailability and Nrf2-related biological activity. Clinical and translational studies on sulforaphane metabolism and Nrf2 pathway activation.
- Ried K, Travica N, Sali A, et al. Effect of garlic on blood pressure: a meta-analysis. Journal of Clinical Hypertension. 2015.
- EFSA. Scientific Opinion on the substantiation of health claims related to vitamin D, vitamin K, vitamin C, vitamin E and selenium. EFSA Journal.
- McEvoy JW, et al. 2024 ESC Guidelines for the management of elevated blood pressure and hypertension. European Heart Journal. 2024;45:3912-4018.
