The management of prediabetes and metabolic syndrome represents a crucial moment of primary prevention in modern endocrinology. Prediabetes is not a simple static condition, but rather a dynamic disorder characterized by impaired fasting glucose (IFG) and/or reduced carbohydrate tolerance (IGT), driven by peripheral insulin resistance and progressive pancreatic beta-cell dysfunction. Frequently, hyperglycemia is associated with atherogenic dyslipidemia (increase in small and dense LDL, hypertriglyceridemia) and a chronic low-grade systemic inflammatory state (low-grade inflammation), which accelerates endothelial damage and progression towards vascular complications.
In this context, complementing lifestyle with a targeted, multi-level, and strictly 100% vegan nutraceutical strategy (free from components or capsules of animal origin) allows for simultaneous intervention on multiple molecular targets: from the deceleration of enteric carbohydrate absorption to the enhancement of hepatic cholesterol clearance, up to the modulation of pro-inflammatory pathways.
PRODUCT_ITEM
RECOMMENDED DOSAGE
To ensure maximum biological efficacy in conjunction with the circadian rhythms of metabolism and meal intake:
· 1 LUNAE tablet at LUNCH: to be taken during or immediately after the meal to modulate the inflammatory response and counteract metabolic oxidative stress.
· 1 DIMALOE capsule at LUNCH and 1 capsule at DINNER: to be taken before or during main meals to optimize appetite control, reduce the absorption of carbohydrates and lipids and improve postprandial insulin sensitivity.
· 1 LIPIDALOE capsule in the EVENING: to be taken after dinner or before going to bed, at the time of maximum activation of endogenous hepatic cholesterol biosynthesis.
CLINICAL AND SCIENTIFIC RATIONALE OF THE MULTITUDO PRODUCTS
1. LIPIDALOE (Intake: 1 capsule in the evening)
100% Vegan Formula
Composition per daily dose (1 capsule):
· Fermented Red Rice (Monascus purpureus): 190 mg (equal to 2.9 mg of total Monacolins)
· Berberis aristata E.S. tit. 85% Berberine HCl: 208 mg (equal to 177 mg of Berberine HCl)
· Vitamin C: 40 mg (50% NRV)
· Vitamin E: 6 mg (50% NRV)
Rationale for use:
LIPIDALOE is formulated to act synergistically on the reduction of plasma cholesterol and the protection of lipoproteins from oxidative stress:
· Inhibition of endogenous synthesis (Monacolin K): Monacolin K acts as a competitive inhibitor of the hepatic HMG-CoA reductase enzyme, reducing the production of endogenous cholesterol during the night. The dosage of 2.9 mg is strictly compliant with European regulatory limits (EU Reg. 2022/860).
· Increase in clearance and AMPK modulation (Berberine HCl): Berberine acts through a complementary and post-receptor mechanism compared to monacolins: it stabilizes the mRNA of the hepatic LDL receptor (LDLR), increasing its expression and promoting the removal of LDL from the circulation. Furthermore, Berberine inhibits the PCSK9 protein (which normally degrades LDLR receptors) and activates the AMPK enzyme, stimulating insulin sensitivity and reducing triglycerides.
· Antioxidant protection of the network (Vitamins C and E): Lipophilic Vitamin E protects LDL lipoproteins from peroxidation (reducing their atherogenicity), while hydrophilic Vitamin C regenerates the active form of Vitamin E, ensuring effective protection from oxidative stress.
DIMALOE (Intake: 1 capsule at lunch and 1 capsule at dinner)
100% Vegan Formula in Vegetable Capsules
Composition per reference daily dose (4 capsules - 1800 mg / adapted to 2 capsules/day):
· Garcinia cambogia E.S. tit. 60% Hydroxycitric Acid (HCA)
· Gymnema sylvestre E.S. tit. 25% Gymnemic Acids
· Coffea arabica (Green Coffee) E.S. tit. 45% Chlorogenic Acids (negligible caffeine)
· Grifola frondosa (Maitake) E.S. tit. 20% Polysaccharides ($\beta$-glucans)
· Griffonia simplicifolia E.S. tit. 20% 5-HTP
· Rosa canina E.S. (Vitamin C) & Vitamin E
· Piper longum (Piperine 90%): bioavailability enhancer
Rationale for use:
DIMALOE provides comprehensive multi-level support for the management of carbohydrate and lipid metabolism and for the control of caloric intake during main meals:
· Slowdown of enteric glucose absorption (Gymnema sylvestre & Green Coffee): Gymnemic acids reversibly bind to intestinal glucose and sucrose receptors, reducing their absorption by up to 50%. Chlorogenic acid from green coffee inhibits the hepatic glucose-6-phosphatase enzyme and reduces intestinal carbohydrate absorption, limiting postprandial glycemic peaks.
· Modulation of lipogenesis and satiety (Garcinia cambogia & Griffonia): Hydroxycitric acid (HCA) inhibits the ATP-citrate lyase enzyme, reducing de novo fatty acid synthesis. 5-HTP (serotonin precursor) acts centrally to regulate mood tone and control appetite and emotional eating.
· Insulin sensitivity and bioavailability (Maitake & Piperine): The polysaccharides of the Maitake mushroom support peripheral insulin sensitivity, while piperine from Piper longum optimizes the absorption and efficacy of the phytochemicals present in the formula.
LUNAE (Dosage: 1 tablet at lunch)
100% Vegan Formula
Composition per daily dose (2 tablets - 2 g / adapted to 1 tablet/day):
· Pineapple (Ananas comosus) E.S. tit. 2500 GDU (Bromelain): 1000 mg
· Boswellia serrata E.S. tit. 65% Boswellic Acids: 500 mg (equivalent to 325 mg of boswellic acids)
· Tetrahydrocurcuminoids (Curcuma longa) Titrated E.S.: 140 mg
Rationale for use:
LUNAE acts as a physiological modulator of low-grade chronic inflammation (low-grade inflammation), common in individuals with insulin resistance and metabolic disorders:
· Control of tissue and intestinal inflammation (Boswellia serrata): Boswellic acids selectively inhibit the 5-lipoxygenase (5-LOX) enzyme, reducing the synthesis of pro-inflammatory leukotrienes. They are particularly useful for protecting the gastrointestinal mucosa and countering inflammatory states.
· Diuretic and anti-edematous action (Bromelain from Pineapple): A highly active proteolytic enzyme (2500 GDU/g) that promotes the drainage of body fluids, improves microcirculation, and contributes to the control of tissue edema.
· Potent antioxidant and systemic activity (Tetrahydrocurcuminoids): They are the primary active metabolites of curcumin; characterized by superior bioavailability and high molecular stability, they neutralize free radicals and support the inflammatory balance of joints, blood vessels, and the intestine.
PLEASE NOTE:
The information provided in the product sheets on this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace the relationship with a doctor or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of food supplements, designed to support the body's balance and well-being within a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or pathological conditions.
SCIENTIFIC AND CLINICAL BIBLIOGRAPHIC REFERENCES
For LIPIDALOE:
1. EFSA NDA Panel. Scientific Opinion on the substantiation of health claims related to monacolin K from red yeast rice. EFSA Journal. 2011;9(7):2304.
2. Cicero AFG, Colletti A, Bajraktari G, et al. Lipid-lowering nutraceuticals in clinical practice: position paper from an International Lipid Expert Panel. Atheroscler Suppl. 2019;40:1-47.
3. Kong W, Wei J, Abidi P, et al. Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins. Nat Med. 2004;10(12):1344-1351.
4. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81.
5. Derosa G, Maffioli P, Cicero AF. Berberis aristata/Silybum marianum fixed combination on lipid profile and insulin secretion in dyslipidemic patients. Expert Opin Biol Ther. 2013;13(11):1495-1503.
For DIMALOE:
6. Heymsfield SB, Allison DB, Vasselli JR, et al. Garcinia cambogia (hydroxycitric acid) as a potential antiobesity agent: a randomized controlled trial. JAMA. 1998;280(18):1596-1600.
7. Baskaran K, Kizar Ahamath B, Shanmugasundaram KR, Shanmugasundaram ER. Antidiabetic effect of a leaf extract from Gymnema sylvestre in non-insulin-dependent diabetes mellitus patients. J Ethnopharmacol. 1990;30(3):295-300.
8. Vinson JA, Burnham BR, Nagendran MV. Randomized, double-blind, placebo-controlled, linear dose, crossover study to evaluate the efficacy and safety of a green coffee bean extract in overweight subjects. Diabetes Metab Syndr Obes. 2012;5:21-27.
9. Cangiano C, Ceci F, Cascino A, et al. Eating behavior and adherence to dietary prescriptions in obese subjects treated with 5-hydroxytryptophan. Am J Clin Nutr. 1992;56(5):863-867.
10. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr. 2007;47(8):735-748.
For LUNAE:
11. Ammon HP. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006;72(12):1100-1116.
12. Rathnavelu V, Alitheen NB, Sohila S, et al. Potential role of bromelain in clinical and therapeutic applications. Biomed Rep. 2016;5(3):283-288.
13. Aggarwal BB, Deb L, Prasad S. Curcumin differs from tetrahydrocurcumin for molecular targets, anti-inflammatory, antioxidant, and anticancer activities. Phytomedicine. 2015;22(1):1-10.
