The digestive system is not only the place designated for the digestion and absorption of nutrients, but also constitutes a biological system highly integrated with the nervous, endocrine, and immune systems. In recent years, research has identified the gut–brain axis as a bidirectional communication network through which the gut and central nervous system mutually influence each other.
Alterations in intestinal motility, changes in microbiota composition, increased intestinal barrier permeability, low-grade inflammatory stimuli, and variations in visceral sensitivity can contribute to the appearance of symptoms such as abdominal bloating, difficult digestion, intestinal tension, bowel alterations, and functional discomfort.
At the same time, conditions of prolonged stress, changes in mood tone, and neurovegetative alterations can reflect on digestive functioning, creating a cycle of symptom maintenance.
Within this integrated view, interest is growing in approaches that simultaneously support the intestinal microenvironment, the balance of the inflammatory response, and the maintenance of physiological digestive function.
PRODUCT_ITEM
1 Cistaloe capsule at lunch and 1 capsule at dinner
1 Lunae tablet at lunch and 1 tablet at dinner
The goal is not to act on a single symptom but to simultaneously support the intestinal environment, digestive physiology, and inflammatory response.
Cistaloe: support for the microbiota and intestinal environment
Cistaloe is a formulation that combines red cranberry extract, turmeric, and a mixture of gastro-protected probiotics including Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Saccharomyces boulardii, and Bacillus coagulans.
Why take 1 capsule at lunch and 1 capsule at dinner
The division into two times of the day arises from the rationale of maintaining a more constant stimulus on the intestinal microenvironment and the interaction between intestinal contents and the mucosa.
The biological rationale can thus be interpreted.
Cranberry provides proanthocyanidins, polyphenolic compounds studied for their antioxidant properties and for the possible modulating effect on the microbiota and the low-grade inflammatory response.
Turmeric provides curcuminoids which in the literature show activity in regulating pro-inflammatory pathways such as NF-kB, modulating oxidative stress, and a possible positive influence on intestinal barrier function.
The probiotic component instead aims to support the balance of the intestinal flora, an element increasingly studied in the gut–brain communication.
A systematic review has highlighted that some probiotics can contribute to the improvement of functional gastrointestinal symptoms and modulate aspects of the neuroendocrine response related to stress.
Clinical studies and meta-analyses also suggest that some strains of Lactobacillus and Saccharomyces may have favorable effects on intestinal barrier integrity, digestive symptoms, and microbiota composition.
Lunae: digestive support and modulation of the inflammatory response
Lunae contains bromelain from pineapple, standardized Boswellia serrata extract, and tetrahydrocurcuminoids derived from turmeric.
Why take 1 tablet at lunch and 1 tablet at dinner
The choice to distribute the intake at the main meals responds to the attempt to physiologically accompany the digestive moment and maintain continuity of support.
The biological rationale includes several levels.
Bromelain is an enzyme complex derived from pineapple studied for the possible support of protein digestion and for modulation activities of the inflammatory response.
Boswellia contains boswellic acids, compounds studied for their effect on the leukotriene cascade and inflammatory processes.
Tetrahydrocurcuminoids represent curcumin metabolites with high antioxidant activity and good bioavailability.
From a theoretical point of view, this association can be interesting when the digestive disorder is accompanied by a feeling of abdominal tension, slowed digestion, and an accentuated perception of intestinal discomfort.
The rationale of the Cistaloe + Lunae combination
The association of the two products should not be interpreted as a treatment of the disease but as a multi-level nutritional strategy:
Cistaloe works mainly on the intestinal environment and the microbiota
Lunae aims to support the digestive moment and the physiological response to inflammatory processes
Their integration fits into the modern concept of support for the gut–brain axis.
To obtain the maximum benefit, it is useful to associate:
regular diet
slow chewing
reduction of excess ultra-processed foods
compatible physical activity
regularity of sleep
stress management
PLEASE NOTE: The information present in the product sheets on this site is exclusively for informative and educational purposes and does not represent a medical opinion. The published contents are not intended to replace the relationship with the doctor nor any medical indications, diagnoses, or prescriptions. The reported information describes the ingredients and characteristics of food supplements, designed as support for the balance and well-being of the organism within a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or pathological conditions.
In case of pharmacological therapies, pregnancy, breastfeeding, or diagnosed pathologies, it is appropriate to consult with the attending physician before use.
Bibliography
Sandhu KV et al. Front Psychiatry. 2017.
Ng QX et al. Nutrients. 2018.
McFarlin BK et al. Nutr J. 2016.
Gupta SC et al. Adv Exp Med Biol. 2013.
Sengupta K et al. Arthritis Research & Therapy. 2008.
Shoba G et al. Planta Medica. 1998.
