Micronutrienti: chiave per l’immunità
on May 23, 2026

Micronutrients: key to immunity

The role of vitamins and minerals in the immune response

The immune system is a complex, highly specialized network that requires an adequate supply of micronutrients to function efficiently. Vitamins and minerals actively contribute to the body's defenses by modulating inflammation, supporting the production of immune cells, and protecting against oxidative stress.

Even a mild deficiency can impair the immune response, increasing susceptibility to infections, particularly respiratory infections.

Vitamin C: antioxidant and immune support

Vitamin C plays a fundamental role in immune defense thanks to its powerful antioxidant activity.

Main functions

Stimulates the production and activity of white blood cells

Reduces oxidative stress during infections

Helps reduce the duration and severity of respiratory symptoms

Vitamin D: a regulator of the immune response

Vitamin D is essential for immune system balance and for controlling inflammatory processes.

Main functions

Modulates the innate and adaptive immune response

Reduces chronic inflammation

Supports defense against respiratory infections

Vitamin A and carotenoids: the mucosal barrier

Vitamin A and carotenoids are essential for maintaining the integrity of mucous membranes, the first line of defense against pathogens.

Main functions

Protection of the respiratory and intestinal mucous membranes

Support for the innate immune response

Vitamin E: protection against oxidative stress

Vitamin E helps protect immune cells from oxidative damage.

Main functions

Supports T-cell activity

Reduces oxidative stress

B vitamins: energy for the immune system

B vitamins are essential for the energy metabolism of immune cells.

Main functions

Support cellular energy production

Promote the proliferation of immune cells

Zinc: defense against infections

Zinc is a key mineral for the proper functioning of the immune system.

Main functions

Regulates T-cell maturation

Reduces the duration of respiratory infections

Iron: oxygen transport and immunity

Iron is involved in numerous physiological processes related to the immune response.

Main functions

Oxygen transport

Antibody production

Copper: antioxidant allies

Copper helps regulate immune defenses through antioxidant enzyme systems.

Main functions

Protection against oxidative stress

Support for immune function

Nutrition and the immune system: how to strengthen your defenses naturally

The immune system is a complex network of specialized cells, lymphatic organs, and chemical mediators that work together to protect the body from viruses, bacteria, and pathogens.

White blood cells represent the first line of defense:

macrophages and granulocytes → rapid, nonspecific response;

B and T lymphocytes → targeted response and immunological memory.

The proper functioning of this system depends not only on genetics, but also on modifiable factors such as nutrition, physical activity, sleep, and stress management.

Nutrition and immune competence: the key role of diet

Nutrition is one of the main determinants of immune health.

Even mild nutritional deficiencies can:

reduce antibody production;

slow the immune response;

increase susceptibility to infections.

A balanced diet provides:

macronutrients → energy and structure;

micronutrients → regulation of immune functions;

fiber → support for the gut microbiota.

Macronutrients: fuel for the immune system

Protein

Essential for the synthesis of antibodies and immune enzymes.

Requirement:

adults: ~0.8 g/kg

over 65: up to 1 g/kg

Recommended sources:

eggs;

legumes;

vegetables.

Essential fats

Omega-3s (EPA and DHA) have anti-inflammatory and immunomodulatory effects.

Sources:

  • vegetable oils;
  • nuts (≈20 g/day).

Carbohydrates and fiber

Choose complex carbohydrates and fiber:

whole grains;

fruit and vegetables;

legumes.

Prebiotic fiber promotes the production of short-chain fatty acids, which have:

anti-inflammatory effects;

protective effects on the intestinal mucosa.

Gut microbiota and immunity

The gut microbiota is now considered a genuine immune organ.

When it is balanced (eubiosis):

improves the response to infections;

modulates inflammation;

supports the response to vaccines.

How to keep it healthy

Probiotics (fermented foods):

yogurt;

kefir;

sauerkraut.

Prebiotics (fiber):

garlic;

onion;

leeks;

bananas;

legumes.

A diet rich in plant-based foods promotes a healthy microbiota, while ultra-processed foods and Western diets promote dysbiosis and inflammation.

Supplementation: when it is useful

The use of supplements may be indicated:

in cases of documented deficiencies;

during periods of greater stress (e.g., winter);

in frail individuals or those with increased requirements.

Possible supplements:

multivitamins;

vitamin D;

omega-3.

It should always be assessed by a healthcare professional.

Immune system and life stages

Children

varied and balanced diet;

adequate intake of omega-3;

balanced breakfast.

Adults

Biomolecular diet;

regular physical activity;

stress management;

adequate hydration.

Elderly

counteracting immunosenescence;

greater attention to proteins and micronutrients;

physical exercise to maintain functionality.

Lifestyle and immunity

In addition to diet, key factors include:

quality sleep;

regular physical activity;

stress management;

reduction of smoking and alcohol.

Immune competence is the result of a complex balance between nutrition, microbiota, and lifestyle.

A balanced diet, rich in nutrients and fiber, combined with a healthy lifestyle, represents the most effective strategy for:

strengthening immune defenses;

reducing inflammation;

improving the body's resilience.

Investing in nutrition means not only preventing disease, but building a more efficient immune system that lasts over time.

Edited by Nico Martini