Aloe vera (Aloe barbadensis Miller)
• Panahi Y, Khedmat H, Valizadegan G, et al. Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial. Journal of Traditional Chinese Medicine. 2015;35(6):632-636.
• Langmead L, Feakins RM, Goldthorpe S, et al. Randomized, double-blind, placebo-controlled trial of oral Aloe vera gel for active ulcerative colitis. Alimentary Pharmacology & Therapeutics. 2004;19(7):739-747.
• Hęś M, Dziedzic K, Górecka D, et al. Aloe vera (L.) Burm. f. as a valuable source of bioactive compounds in food, medicine and cosmetics. Nutrients. 2022;14:998.
• Surjushe A, Vasani R, Saple DG. Aloe vera: a short review. Indian Journal of Dermatology. 2008;53(4):163-166.
• Radha MH, Laxmipriya NP. Evaluation of biological properties and clinical effectiveness of Aloe vera: a systematic review. Journal of Traditional and Complementary Medicine. 2015;5(1):21-26.
• Hamman JH. Composition and applications of Aloe vera leaf gel. Molecules. 2008;13:1599-1616.
Vitamina C (Acido L-Ascorbico)
• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on Dietary Reference Values for vitamin C. EFSA Journal. 2013;11(11):3418.
• Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017;9(11):1211.
• Carr AC, Rowe S. The Emerging Role of Vitamin C in Immune Function and Disease Prevention. Nutrients. 2020;12:3286.
• Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System. Nutrients. 2020;12:236.
• Gröber U, et al. Micronutrients in immune function. Nutrients. 2020;12:236.
Vitamina E
• EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on Dietary Reference Values for Vitamin E. EFSA Journal. 2015;13(7):4149.
• Traber MG. Vitamin E Regulatory Mechanisms. Annual Review of Nutrition. 2021;41:257-276.
• Niki E. Role of Vitamin E as a Lipid-Soluble Peroxyl Radical Scavenger. Free Radical Biology and Medicine. 2014;66:3-12.
• Azzi A. Many tocopherols, one vitamin E. Molecular Aspects of Medicine. 2018;61:92-103.
Olio essenziale di Niaouli (Melaleuca quinquenervia)
• Sharifi-Rad J, Salehi B, et al. Melaleuca genus: botanical characteristics, phytochemistry and pharmacology. Phytotherapy Research. 2023.
• Carson CF, Hammer KA, Riley TV. Melaleuca alternifolia (Tea Tree Oil): a Review of Antimicrobial and Other Medicinal Properties. Clinical Microbiology Reviews. 2006;19:50-62.
• European Medicines Agency (EMA). Assessment reports and monographs on Melaleuca species.
• Bakkali F, Averbeck S, Averbeck D, Idaomar M. Biological effects of essential oils – A review. Food and Chemical Toxicology. 2008;46:446-475.
Olio essenziale di Arancio dolce (Citrus sinensis)
• Singh B, Singh JP, Kaur A, Singh N. Bioactive compounds in citrus fruits and their health-promoting properties. Food Research International. 2020.
• Favela-Hernández JMJ, et al. Chemistry and Pharmacology of Citrus Essential Oils. Molecules. 2016;21:247.
• Dosoky NS, Setzer WN. Biological Activities and Safety of Citrus Essential Oils. International Journal of Molecular Sciences. 2018;19:1966.
Olio essenziale di Limone (Citrus limon)
• Klimek-Szczykutowicz M, Szopa A, Ekiert H. Citrus limon (Lemon): Chemistry, Traditional Uses, Biological Activity and Applications. Plants. 2020;9:119.
• Gharibi S, et al. Pharmacological properties of Citrus limon: A comprehensive review. Journal of Herbal Medicine. 2022.
• Sharma K, Mahato N, et al. Bioactive Compounds and Biological Activities of Citrus Species. Food Bioscience. 2021.
Evidenze sul benessere gastrointestinale
• Ford AC, et al. Functional Dyspepsia. Lancet. 2020;396:1689-1702.
• Black CJ, Ford AC. Global burden of gastrointestinal disorders. The Lancet Gastroenterology & Hepatology. 2020.
• Moayyedi P, et al. ACG Clinical Guideline: Management of Gastroesophageal Reflux Disease. American Journal of Gastroenterology. 2022.
Stress ossidativo e antiossidanti
• Sies H. Oxidative Stress: Concept and Some Practical Aspects. Antioxidants. 2020;9:852.
• Liguori I, et al. Oxidative stress, aging, and diseases. Clinical Interventions in Aging. 2018;13:757-772.
Sistema immunitario e micronutrienti
• Gombart AF, Pierre A, Maggini S. A Review of Micronutrients and the Immune System. Nutrients. 2020;12:236.
• Calder PC. Nutrition, immunity and COVID-19. BMJ Nutrition, Prevention & Health. 2020;3:74-92.
• Maggini S, Pierre A, Calder PC. Immune Function and Micronutrients. Nutrients. 2018;10:1531.
Riferimenti normativi
• Direttiva 2002/46/CE relativa agli integratori alimentari.
• Regolamento (CE) n. 1924/2006 relativo alle indicazioni nutrizionali e sulla salute fornite sui prodotti alimentari.
• Regolamento (UE) n. 432/2012 recante l'elenco delle indicazioni sulla salute consentite.
• Regolamento (UE) n. 1169/2011 relativo alla fornitura di informazioni sugli alimenti ai consumatori.
• Regolamento (UE) 2021/468 relativo alle preparazioni contenenti derivati idrossiantracenici dell'Aloe.
• Decreto del Ministero della Salute 10 agosto 2018 e successivi aggiornamenti (Lista BELFRIT delle piante e preparati vegetali ammessi negli integratori alimentari).
• EFSA (European Food Safety Authority). Scientific Opinions on Dietary Reference Values for Vitamins and Minerals.