Le evidenze scientifiche riportate nella presente scheda derivano da studi clinici, revisioni sistematiche, meta-analisi, documenti di consenso e pareri delle principali autorità scientifiche internazionali.
Fibre alimentari, salute intestinale e microbiota
1. Gibson GR, Hutkins R, Sanders ME, et al. Expert consensus document: The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics. Nature Reviews Gastroenterology & Hepatology. 2017;14(8):491-502.
2. Slavin JL. Fiber and Prebiotics: Mechanisms and Health Benefits. Nutrients. 2013;5(4):1417-1435.
3. Makki K, Deehan EC, Walter J, Bäckhed F. The Impact of Dietary Fiber on Gut Microbiota in Host Health and Disease. Cell Host & Microbe. 2018;23(6):705-715.
4. Sonnenburg ED, Sonnenburg JL. Starving our microbial self: the deleterious consequences of a diet deficient in microbiota-accessible carbohydrates. Cell Metabolism. 2014;20(5):779-786.
5. Valdes AM, Walter J, Segal E, Spector TD. Role of the gut microbiota in nutrition and health. BMJ. 2018;361.
6. Holscher HD. Dietary Fiber and Prebiotics and the Gastrointestinal Microbiota. Gut Microbes. 2017;8(2):172-184.
Psyllio (Plantago ovata)
7. McRorie JW Jr, Fahey GC Jr. A Review of Gastrointestinal Physiology and the Mechanisms Underlying the Health Benefits of Dietary Fiber. Journal of AOAC International. 2015;98(1):53-63.
8. McRorie JW Jr. Evidence-based approach to fiber supplements and clinically meaningful health benefits. Nutrition Today. 2015;50(2):82-89.
9. McRorie JW Jr, McKeown NM. Understanding the Physics of Functional Fibers in the Gastrointestinal Tract. American Journal of Gastroenterology. 2017;112:173-182.
10. Anderson JW, Allgood LD, Lawrence A, et al. Cholesterol-lowering effects of psyllium intake. American Journal of Clinical Nutrition. 2000;71:472-479.
11. EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA). Scientific Opinion on the substantiation of a health claim related to psyllium and maintenance of normal blood cholesterol concentrations. EFSA Journal. 2010;8(10):1739.
12. Müller-Lissner SA, Kamm MA, Scarpignato C, et al. Myths and misconceptions about chronic constipation. American Journal of Gastroenterology. 2005;100:232-242.
Gomma di Guar
13. Jenkins DJA, Leeds AR, Gassull MA, et al. Decrease in postprandial insulin and glucose concentrations by guar and pectin. Lancet. 1978;2:172-174.
14. Brown L, Rosner B, Willett WW, Sacks FM. Cholesterol-lowering effects of dietary fiber: a meta-analysis. American Journal of Clinical Nutrition. 1999;69:30-42.
15. Slavin JL, Green H. Dietary fibre and satiety. Nutrition Bulletin. 2007;32(S1):32-42.
16. Dikeman CL, Fahey GC. Viscous dietary fibres and metabolic health. Journal of Nutrition. 2006;136:2641-2644.
Frutto-oligosaccaridi (FOS)
17. Roberfroid MB. Prebiotics: The Concept Revisited. Journal of Nutrition. 2007;137:830S-837S.
18. Bouhnik Y, Vahedi K, Achour L, et al. Short-chain fructo-oligosaccharide administration dose-dependently increases fecal bifidobacteria. Journal of Nutrition. 1999;129:113-116.
19. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota. Journal of Nutrition. 1995;125:1401-1412.
20. Scott KP, Gratz SW, Sheridan PO, et al. The influence of diet on the gut microbiota. Pharmacological Research. 2013;69:52-60.
Fibre e metabolismo glucidico
21. Reynolds A, Mann J, Cummings J, et al. Carbohydrate quality and human health: systematic review and meta-analysis. The Lancet. 2019;393:434-445.
22. Weickert MO, Pfeiffer AFH. Impact of dietary fiber consumption on insulin resistance and prevention of type 2 diabetes. Journal of Nutrition. 2018;148:7-12.
23. Post RE, Mainous AG, King DE, Simpson KN. Dietary fiber for the treatment of type 2 diabetes mellitus. Journal of the American Board of Family Medicine. 2012;25:16-23.
Fibre e colesterolo
24. Soliman GA. Dietary Fiber, Atherosclerosis and Cardiovascular Disease. Nutrients. 2019;11:1155.
25. Threapleton DE, Greenwood DC, Evans CEL, et al. Dietary fibre intake and risk of cardiovascular disease. BMJ. 2013;347.
26. Ho HVT, Sievenpiper JL, Zurbau A, et al. The effect of dietary fibre on LDL cholesterol: systematic review and meta-analysis. The Lancet Regional Health. 2023.
Microbiota e barriera intestinale
27. Koh A, De Vadder F, Kovatcheva-Datchary P, Bäckhed F. From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites. Cell. 2016;165:1332-1345.
28. Louis P, Flint HJ. Formation of propionate and butyrate by the human colonic microbiota. Environmental Microbiology. 2017;19:29-41.
29. Parada Venegas D, et al. Short Chain Fatty Acids and Human Health. Frontiers in Immunology. 2019;10:277.
30. Rinninella E, Raoul P, Cintoni M, et al. What is the Healthy Gut Microbiota Composition? Microorganisms. 2019;7:14.
Linee guida e documenti istituzionali
31. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA). Scientific opinions on dietary fibre and health claims.
32. World Gastroenterology Organisation (WGO). Global Guidelines – Constipation. Aggiornamento più recente.
33. American Gastroenterological Association (AGA). Clinical Practice Update on Chronic Constipation.
34. British Society of Gastroenterology. Guidelines on the management of chronic constipation in adults.
35. Ministero della Salute. Linee guida sugli integratori alimentari e botanicals. Ultima revisione disponibile.
36. Regolamento (CE) n. 1924/2006 relativo alle indicazioni nutrizionali e sulla salute fornite sui prodotti alimentari.
37. Regolamento (UE) n. 432/2012 che stabilisce l'elenco delle indicazioni sulla salute consentite.
38. Regolamento (UE) n. 1169/2011 relativo alla fornitura di informazioni sugli alimenti ai consumatori.
39. Direttiva 2002/46/CE relativa agli integratori alimentari.
40. Decreto Legislativo 21 maggio 2004 n. 169, attuazione della Direttiva 2002/46/CE.
Conclusioni scientifiche
La letteratura scientifica disponibile conferma che l'associazione di psillio, gomma di guar e frutto-oligosaccaridi (FOS) rappresenta una strategia nutrizionale supportata da solide evidenze per incrementare l'apporto di fibre alimentari, favorire la fisiologica regolarità intestinale, sostenere l'equilibrio del microbiota e contribuire al normale metabolismo glucidico e lipidico. Le quantità presenti in AloeFibra Naturocare sono coerenti con i dosaggi impiegati nei principali studi clinici e con i pareri delle autorità scientifiche europee.