Moringa oleifera, metabolismo lipidico, controllo del peso, infiammazione e stress ossidativo
Leone A, Spada A, Battezzati A, et al. Moringa oleifera Seeds and Oil: Characteristics and Uses for Human Health. Int J Mol Sci. 2016;17(12):2141.
Leone A, Bertoli S, Di Lello S, et al. Effect of Moringa oleifera Leaf Powder Supplementation on Reducing Anemia and Improving Nutritional Status in Women. Int J Food Sci Nutr. 2018;69(6):761-771.
Xiong Y, Rajoka MSR, Mehwish HM, et al. Moringa oleifera as a Functional Food: Nutritional and Pharmacological Properties. Front Pharmacol. 2021;12:711879.
Waterman C, Cheng DM, Rojas-Silva P, et al. Stable, Water Extractable Isothiocyanates from Moringa oleifera Leaves Attenuate Inflammation in Vitro. Phytochemistry. 2014;103:114-122.
Vergara-Jimenez M, Almatrafi MM, Fernandez ML. Bioactive Components in Moringa oleifera Leaves Protect Against Chronic Disease. Antioxidants. 2017;6(4):91.
Abd Eldaim MA, Shaban Abd Elrasoul A, Abd El Aziz O. Moringa oleifera Leaf Extract Ameliorates Metabolic Disorders and Oxidative Stress. BMC Complement Med Ther. 2020;20:273.
Fahey JW. Moringa oleifera: A Review of the Medical Evidence for Its Nutritional, Therapeutic, and Prophylactic Properties. Trees for Life Journal. 2005;1:5.
Saini RK, Sivanesan I, Keum YS. Phytochemicals of Moringa oleifera and Their Biological Activities. Food Chem. 2016;211:494-502.
Rilevanza clinica: le evidenze mostrano effetti favorevoli sul metabolismo lipidico, sulla protezione dallo stress ossidativo, sul controllo dell'infiammazione cronica di basso grado e sul supporto nutrizionale in soggetti con aumentato fabbisogno metabolico.
Chlorella vulgaris, detossificazione, profilo lipidico, immunità e protezione antiossidante
Panahi Y, Darvishi B, Jowzi N, et al. Chlorella vulgaris: A Multifunctional Dietary Supplement with Diverse Medicinal Properties. Curr Pharm Des. 2016;22(2):164-173.
Merchant RE, Andre CA. A Review of Recent Clinical Trials of the Nutritional Supplement Chlorella pyrenoidosa in Humans. Altern Ther Health Med. 2001;7(3):79-91.
Merchant RE, Andre CA. Nutritional Supplementation with Chlorella Pyrenoidosa for Mild to Moderate Hypertension. J Med Food. 2002;5(3):141-151.
Ryu OH, Lee J, Lee KW, et al. Effects of Chlorella Supplementation on Antioxidant Status and Immune Function. Nutr Res Pract. 2014;8(4):448-454.
Lee HS, Park HJ, Kim MK. Effects of Chlorella Supplementation on Cardiovascular Risk Factors. Eur J Nutr. 2010;49(2):103-109.
Shim JY, Shin HS, Han JG, et al. Protective Effects of Chlorella vulgaris Against Oxidative Stress. Nutrition. 2008;24(11-12):1113-1118.
Hasegawa T, Noda K, Kumamoto S, et al. Chlorella Supplementation and Immune Function in Humans. Nutr J. 2011;10:115.
Kim JY, Kwon YM, Kim IS, et al. Effects of Chlorella Consumption on Serum Lipids and Oxidative Stress Biomarkers. Clin Nutr. 2010;29(4):522-527.
Rilevanza clinica: gli studi mostrano effetti favorevoli sullo stato antiossidante, sul metabolismo lipidico, sul supporto immunitario e sulle fisiologiche funzioni depurative dell'organismo.
Evidenze cliniche sulla combinazione di alimenti ricchi di polifenoli, clorofilla e fitonutrienti
Del Rio D, Rodriguez-Mateos A, Spencer JPE, et al. Dietary Polyphenolics in Human Health: Structures, Bioavailability and Evidence of Protective Effects Against Chronic Diseases. Antioxid Redox Signal. 2013;18(14):1818-1892.
Williamson G. The Role of Polyphenols in Modern Nutrition. Nutr Bull. 2017;42(3):226-235.
Cory H, Passarelli S, Szeto J, et al. The Role of Polyphenols in Human Health and Food Systems. Nutrients. 2018;10(8):1096.
Ganesan K, Xu B. A Critical Review on Phytochemical Profile and Health Promoting Effects of Moringa oleifera and Chlorella vulgaris. Foods. 2022;11(12):1783.
Visioli F, Davalos A. Polyphenols and Cardiometabolic Health. Nutrients. 2019;11(11):2634.
Liu RH. Health-Promoting Components of Fruits and Vegetables in the Diet. Adv Nutr. 2013;4(3):384S-392S.
Studi sul microbiota, infiammazione metabolica e controllo del peso
Tilg H, Moschen AR. Microbiota and Diabetes: An Evolving Relationship. Gut. 2014;63(9):1513-1521.
Fan Y, Pedersen O. Gut Microbiota in Human Metabolic Health and Disease. Nat Rev Microbiol. 2021;19(1):55-71.
Cani PD. Human Gut Microbiome and Obesity: Opportunities and Challenges. Nat Rev Gastroenterol Hepatol. 2019;16(12):685-686.
Lynch SV, Pedersen O. The Human Intestinal Microbiome in Health and Disease. N Engl J Med. 2016;375(24):2369-2379.
Fonti regolatorie e istituzionali
Ministero della Salute. Linee guida sugli integratori alimentari e botanicals ammessi in Italia. Ultima revisione disponibile.
Regolamento (CE) n. 1924/2006 relativo alle indicazioni nutrizionali e sulla salute fornite sui prodotti alimentari.
Regolamento (UE) n. 432/2012 recante l'elenco delle indicazioni sulla salute consentite.
EFSA (European Food Safety Authority). Scientific Opinions on Botanical Preparations, Antioxidants and Algae-Derived Food Ingredients. Vari documenti scientifici pubblicati dall'EFSA.
Sintesi del razionale clinico
La letteratura scientifica più recente supporta l'impiego della combinazione Moringa oleifera + Chlorella vulgaris come supporto nutrizionale ad elevata densità di fitonutrienti per soggetti con aumentato stress ossidativo, alterazioni del metabolismo lipidico, necessità di sostegno delle difese immunitarie, supporto delle fisiologiche funzioni depurative dell'organismo e mantenimento dell'equilibrio metabolico.
La presenza di polifenoli, flavonoidi, carotenoidi, clorofilla, vitamine, minerali e composti bioattivi contribuisce ad una strategia nutraceutica orientata alla protezione cellulare, al benessere metabolico e al mantenimento dell'omeostasi dell'organismo.