OR CYST OPUS RURI | Urinary Tract Wellness with D-Mannose, Cranberry, Bergamot and Antioxidant Vitamins | Syrup 500 ml

OR CYST is designed for:
• Women prone to occasional or recurrent cystitis.
• Men with urinary tract disorders or bacterial prostatitis.
• People who wish to maintain urinary tract health throughout the year.
• Those who want to support the body's natural defenses against urinary tract infections.
• Those who desire natural support before, during, and after any urinary tract treatments.
• Men and women seeking daily prevention of urinary tract problems.

OR Cyst is designed for adults who wish to physiologically support urinary tract health through targeted supplementation based on ingredients studied in clinical settings.

It can provide valuable nutritional support for people prone to recurrent episodes of lower urinary tract disorders, particularly women predisposed to recurrent cystitis, a group in which cranberry and D-mannose have been most extensively studied in randomized clinical trials and systematic reviews.

It is indicated for those who wish to promote the maintenance of the physiological cleansing of the urinary tract through the combination of D-mannose and type A proanthocyanidins, two ingredients that act through different but complementary mechanisms to reduce the adhesion of the main uropathogenic bacteria to the urothelium.

The formulation is also suitable for those who wish to support the body's natural antioxidant defenses thanks to the presence of bergamot polyphenols and vitamins C and E, nutrients involved in protecting cells from oxidative stress and supporting the normal function of the immune system.

It can be used during periods when particular attention is desired for the health of the urinary tract, during seasonal changes, after periods of intense stress, or when physiological factors may alter the normal balance of the urinary tract.

The supplement does not replace any therapies prescribed by a doctor nor is it intended for the treatment of acute urinary tract infections.

In case of ongoing symptoms
Take 40 ml daily, preferably divided into two/four doses.

For prevention, take 20 ml daily.

Shake well before use.

OR Cyst was developed in line with the Moltitudo formulation philosophy: to use exclusively ingredients with a clear physiological rationale and supported by scientific literature.
The formulation combines bergamot juice, naturally rich in flavonoids, with D-mannose and cranberry with a high proanthocyanidin (PAC) content, completing the profile with Vitamin C and Vitamin E, nutrients involved in protecting cells from oxidative stress.
Each ingredient has been selected to contribute to a different physiological mechanism, offering an integrated approach to urinary tract well-being.
The formulation is developed without superfluous ingredients, prioritizing raw material quality, compositional simplicity, and transparency.

Ingredients per daily dose (40 ml)
• Bergamot (Citrus x bergamia Risso & Poit.), fruit juice: 38 g
• D-mannose (from Betula pendula Roth): 1000 mg
• Cranberry (Vaccinium macrocarpon Aiton) dry extract standardized to 40% Proanthocyanidins (PACs): 400 mg
or equivalent to 160 mg of PACs
• Vitamin C: 80 mg equivalent to 100% NRV
• Vitamin E: 12 mg equivalent to 100% NRV

The formulation of OR Cyst was developed based on a scientific rationale that integrates ingredients with complementary physiological mechanisms.
D-Mannose has been extensively studied for its ability to bind to type 1 fimbriae of Escherichia coli, limiting its adhesion to the bladder mucosa and promoting its elimination through the urinary flow. Randomized clinical studies have observed a reduction in cystitis recurrence in predisposed subjects compared to no treatment.
Cranberry extract standardized in type A proanthocyanidins contributes to the maintenance of the physiological functionality of the urinary tract. The most recent systematic reviews and meta-analyses report a benefit especially in people with recurrent urinary tract infections, thanks to the anti-adhesive mechanism exerted on the main bacterial species responsible for cystitis.
The flavonoids naturally present in Bergamot juice provide an important antioxidant activity documented in numerous clinical and experimental studies, contributing to the maintenance of cellular oxidative balance.
Vitamin C contributes to the normal function of the immune system, the protection of cells from oxidative stress, and the normal formation of collagen, which is also fundamental for the integrity of the mucous membranes.
Vitamin E contributes to the protection of cells from oxidative damage to cell membranes, completing the physiological antioxidant network together with Vitamin C.
The combination of these ingredients provides complete nutritional support aimed at maintaining the well-being of the urinary tract, antioxidant protection, and supporting the body's physiological defenses, using dosages consistent with those most documented in international scientific literature.

What is OR Cyst used for?
OR Cyst is a food supplement designed to support the physiological well-being of the urinary tract through a combination of D-Mannose, high-PAC Cranberry, Bergamot, and antioxidant vitamins.

Is OR Cyst an antibiotic?
No. OR Cyst is a food supplement and is not a medicine. It does not replace any therapies prescribed by a doctor.

What is D-Mannose?
D-Mannose is a simple sugar that is primarily eliminated through urine and has been extensively studied for its role in reducing the adhesion of Escherichia coli to the urothelium.

Why does it contain Cranberry?
Cranberry provides type A proanthocyanidins (PAC), natural compounds studied for their anti-adhesive mechanism against the main bacteria responsible for recurrent urinary tract infections.

What is the role of Bergamot?
Bergamot juice is naturally rich in flavonoids with antioxidant activity that contribute to maintaining the body's redox balance.

Why does it contain Vitamin C?
Vitamin C contributes to the normal function of the immune system and to the protection of cells from oxidative stress according to the claims authorized by the European Union.

Why does it also contain Vitamin E?
Vitamin E contributes to the protection of cells from oxidative damage to cell membranes, complementing the action of Vitamin C.

Who can use OR Cyst?
It is indicated for adults who wish to support the physiological well-being of the urinary tract and support the body's antioxidant defenses.

How long can it be taken?
The duration of supplementation may vary depending on individual needs. For prolonged use, it is advisable to consult your doctor or healthcare professional.

Is it also suitable for men?
Yes. Although clinical studies have been conducted mainly in women with recurrent urinary tract infections, the ingredients in the formulation can also be used by men for the physiological well-being of the urinary tract.

Can OR Cyst be taken with antibiotics?
The supplement does not replace antibiotic therapy. In the case of a urinary tract infection under treatment, it is advisable to follow the doctor's instructions.

Does the product contain high amounts of proanthocyanidins?
Yes. The daily dose provides 160 mg of PAC, an amount higher than the dosages most studied in the scientific literature for supporting the well-being of the urinary tract.

Is it necessary to drink plenty of water while taking it?
Proper hydration is always an important element for the physiological well-being of the urinary tract and can accompany the use of the supplement as part of a healthy lifestyle.

The formulation of OR Cyst was developed by selecting ingredients supported by international scientific literature for maintaining urinary tract health, protecting against oxidative stress, and supporting the body's natural defenses. The evidence reported below concerns the individual ingredients in the formulation and not the finished product.

Bergamot (Citrus × bergamia Risso & Poit.)
Bergamot juice is a rich natural source of flavanones, including neoeriocitrin, naringin, and neohesperidin, as well as other polyphenols with antioxidant activity. Numerous clinical studies and reviews have shown that these compounds help maintain cellular redox balance and support metabolic and vascular function. Although bergamot does not act directly on the urinary tract, its antioxidant activity provides valuable support in protecting cells from oxidative stress.
Key scientific references
Mollace V, et al. Fitoterapia. 2011.
Toth PP, et al. Frontiers in Pharmacology. 2015.
Gliozzi M, et al. Bergamot polyphenolic fraction: evidence from experimental and clinical studies. Frontiers in Pharmacology. 2021.

Cranberry (Vaccinium macrocarpon Aiton)
Cranberry is one of the botanicals most extensively studied for urinary tract health. Type A proanthocyanidins (PACs) can interfere with the adhesion of Escherichia coli to the urothelium, reducing one of the main mechanisms involved in the development of recurrent urinary tract infections.
The most recent systematic reviews and guidelines state that cranberry consumption may reduce the risk of recurrence in predisposed individuals, particularly women with recurrent urinary tract infections. Its effectiveness depends on the quality of the extract and its PAC content.
Key scientific references
Howell AB, et al. A-type cranberry proanthocyanidins and bacterial anti-adhesion. Phytochemistry. 2005.
Fu Z, et al. Cranberry reduces the risk of urinary tract infection recurrence: systematic review and meta-analysis. American Journal of Clinical Nutrition. 2017.
Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2023 Update.
Prevention of Recurrent Urinary Tract Infection in Women: An Update. Medicina. 2025.

D-Mannose
D-mannose is a simple sugar that is primarily eliminated through urine. Its biological rationale is based on its ability to bind to type 1 fimbriae of Escherichia coli, preventing it from adhering to the urinary epithelium and promoting its physiological elimination with the flow of urine.
Clinical studies published in previous years had shown favorable results in reducing cystitis recurrence. More recent randomized studies, however, have reported less conclusive results when D-mannose is used as the sole intervention. The most up-to-date systematic reviews indicate that the biological rationale remains plausible, but further high-quality studies are needed to more precisely define its clinical role.
Key scientific references
Kranjčec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections. World Journal of Urology. 2014.
Porru D, et al. Oral D-mannose in recurrent urinary tract infections. European Review for Medical and Pharmacological Sciences. 2014.
Hayward G, et al. D-Mannose for Prevention of Recurrent Urinary Tract Infection Among Women: A Randomized Clinical Trial. JAMA Internal Medicine. 2024.
Systematic Review and Meta-analysis of Randomized Controlled Trials on D-Mannose for Recurrent UTI. 2025.

Vitamin C
Vitamin C contributes to the normal function of the immune system, the protection of cells from oxidative stress, and the normal formation of collagen, as recognized by the European Union's authorized health claims.
Physiologically, it participates in cellular antioxidant systems and contributes to the regeneration of oxidized vitamin E, supporting the body's antioxidant defense network.
Key scientific references
Carr AC, Maggini S. Vitamin C and immune function. Nutrients. 2017.
EFSA NDA Panel. Scientific Opinion on Vitamin C and immune function.
Regulation (EU) No 432/2012 – Authorized Health Claims.

Vitamin E
Vitamin E is the main fat-soluble antioxidant in cell membranes. It protects phospholipids from peroxidation and helps maintain cellular integrity.
Its combination with vitamin C is well documented due to the complementary nature of their respective antioxidant systems.
Key scientific references
Traber MG, Stevens JF. Vitamin E in human health. Free Radical Biology and Medicine. 2011.
EFSA NDA Panel. Scientific Opinion on Vitamin E.
Regulation (EU) No 432/2012 – Authorized Health Claims.

Rationale for the synergistic formulation
OR Cyst was developed using a multi-target physiological approach.
Cranberry provides type A proanthocyanidins that help reduce the adhesion of the main uropathogenic bacteria.
D-mannose offers an additional anti-adhesion mechanism, particularly against Escherichia coli, although more recent literature suggests that further clinical evidence is needed to confirm its use as the sole preventive intervention.
Bergamot polyphenols help protect against oxidative stress and maintain redox balance.
Vitamin C and vitamin E complete the body's natural antioxidant network, helping to protect cells from oxidative damage and support the normal function of the immune system.
The combination of ingredients with different physiological mechanisms follows a formulation rationale aimed at simultaneously supporting urinary tract health, antioxidant protection, and the body's natural defenses.

General bibliography
Gliozzi M, et al. Frontiers in Pharmacology. 2021.
Hayward G, et al. JAMA Internal Medicine. 2024.
Howell AB, et al. Phytochemistry. 2005.
Jepson RG, Williams G, Craig JC. Cochrane Database of Systematic Reviews. 2023.
Carr AC, Maggini S. Nutrients. 2017.
Kranjčec B, et al. World Journal of Urology. 2014.
Porru D, et al. European Review for Medical and Pharmacological Sciences. 2014.
Mollace V, et al. Fitoterapia. 2011.
Toth PP, et al. Frontiers in Pharmacology. 2015.
Traber MG, Stevens JF. Free Radical Biology and Medicine. 2011.
Systematic Review and Meta-analysis of D-Mannose in Recurrent UTI. 2025.
Prevention of Recurrent Urinary Tract Infection in Women: An Update. Medicina. 2025.

Food supplement. Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement or food supplement, it is important to consult your doctor or therapist before use during pregnancy or breastfeeding, when taking medication, in case of various illnesses or medical conditions, or in view of any kind of medical procedure. Discontinue use in case of adverse reactions and consult your doctor or therapist.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace consultation with a doctor or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of food supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.