PROSTATE PRIME OPUS RURI | Natural Support for Prostate and Urinary Tract | 90 Plant-Based Capsules 450 mg

Prostata Prime is designed for adult men who wish to take preventive measures and naturally support prostate function and daily urinary comfort.
It is particularly suitable for those who:
• have a family history of prostate cancer and want preventive support;
• want to supplement their diet with plant compounds studied for prostate health;
• are looking for a concentrated source of epigallocatechins, lycopene, resveratrol, and curcuminoids;
• want to support the natural balance of the urinary tract;
• want a natural supplement without preservatives or unnecessary additives;
• are looking for a complete formula for men’s well-being after age 45.

It is recommended to take 4 vegetable capsules daily, preferably divided during main meals, accompanied by plenty of water.

. Ingredients (per daily dose – 4 capsules)
Green Tea (Camellia sinensis (L.) Kuntze), leaves, dry extract standardized to ≥95% polyphenols, 300 mg, equivalent to 285 mg of total polyphenols, 225 mg of catechins, 135 mg of EGCG and 9 mg of caffeine.
Pomegranate (Punica granatum L.), fruit, dry extract standardized to ≥20% ellagic acid, 300 mg, equivalent to 60 mg of ellagic acid.
Turmeric (Curcuma longa L.), rhizome, dry extract standardized to ≥95% curcuminoids, 300 mg, equivalent to 285 mg of curcuminoids.
Broccoli (Brassica oleracea L.), leaves, dry extract standardized to 0.3–0.5% sulforaphane, 100 mg, equivalent to 0.5 mg of sulforaphane.
Siberian Ginseng (Eleutherococcus senticosus), root, dry extract standardized to ≥2% eleutherosides, 100 mg, equivalent to 2 mg of eleutherosides.
Reishi (Ganoderma lucidum), mushroom, dry extract standardized to ≥30% polysaccharides, 100 mg, equivalent to 30 mg of polysaccharides.
Agaricus blazei (Agaricus blazei Murill), mushroom, dry extract standardized to ≥10% polysaccharides, 100 mg, equivalent to 10 mg of polysaccharides.
Quercetin from Sophora japonica, ≥98% purity, 100 mg.
Echinacea (Echinacea angustifolia DC.), root, dry extract standardized to ≥0.1% echinacoside, 100 mg, equivalent to 0.1 mg of echinacoside.
Bearberry (Arctostaphylos uva-ursi), leaves, dry extract standardized to ≥10% arbutin, 100 mg, equivalent to 10 mg of arbutin.
Tomato Lycopene (Solanum lycopersicum L.), dry extract standardized to ≥6%, 100 mg, equivalent to 6 mg of lycopene.
Polygonum cuspidatum (Fallopia japonica), root, dry extract standardized to ≥20% resveratrol, 100 mg, equivalent to 20 mg of resveratrol.

The formula of Prostata Prime is designed to provide synergistic support thanks to the combination of selected ingredients.
Promotes the normal balance of the urinary tract.
Provides a high content of natural antioxidants.
Helps counteract oxidative stress, one of the main factors affecting cellular well-being.
Supports the body's physiological inflammatory balance.
Offers targeted nutritional support thanks to green tea, lycopene, resveratrol, pomegranate, and turmeric.
Complements the diet with some of the most studied plant compounds for prostate health.
Supports the body's natural defenses thanks to the presence of reishi, agaricus blazei, and echinacea.
Contributes to overall tone and vitality thanks to eleuthero.

What is Prostata Prime used for?
Prostata Prime is a natural food supplement formulated to support prostate and urinary tract health through a combination of selected plant extracts and phytonutrients.
What is the scientific rationale behind the formula?
The formula is inspired by the latest evidence presented at the 94th SIU National Congress, which highlighted the role of green tea epigallocatechins, lycopene, and resveratrol in supporting prostate health for individuals with a family history of prostate cancer.
Why does it contain green tea, pomegranate, and lycopene?
Green tea provides epigallocatechins, pomegranate provides ellagic acid, and lycopene is one of the most studied carotenoids for men's health and antioxidant support.
Can Prostata Prime be taken every day?
Yes, by following the recommended daily dose stated on the label.
Is it suitable for those following a vegetarian or vegan diet?
Yes. The product uses only plant-based capsules.
Does it contain preservatives or additives?
No. The formulation is made without preservatives, without added chemicals, and without unnecessary additives.
What evidence was presented at the 94th SIU National Congress on prostate cancer?
Recent findings presented at the 94th SIU National Congress have shown that certain substances found in specific foods have significant antioxidant, anti-inflammatory, and antiproliferative properties useful for urinary tract health. In particular, tea epigallocatechins, lycopene, resveratrol, and pterostilbene have been identified as particularly effective. Green tea and tomatoes are rich sources of epigallocatechins and lycopene. A clinical study conducted on a group of men at high risk of prostate cancer revealed that regular consumption of green tea epigallocatechins reduced the risk of developing the disease by 60% compared to those who received a placebo. Furthermore, continuous intake for two years can potentially reduce the risk by up to 80%. In the prevention phase, lycopene was identified as a particularly suitable component, as indicated by a meta-analysis of 42 studies involving nearly 700,000 participants. It has been shown that this active ingredient, found in abundance in tomatoes, has a protective effect second only to the epigallocatechins found in green tea. Clinical studies show that supplementing your diet with lycopene can reduce the risk of developing prostate cancer by 12%, a percentage that rises to 26% for the more aggressive forms of the disease. While the preventive properties of green tea and tomatoes have long been recognized, recent research has highlighted the effectiveness of grapes, thanks to the presence of resveratrol. This compound not only helps prevent prostate cancer but also supports anti-tumor treatments. The key factor that makes this possible is the remarkable antioxidant power that works on two fronts; in the early stages of cancer, it blocks certain factors, while in later stages, it prevents their progression. Another very interesting active ingredient that was discussed was pterostilbene, a prostate-friendly antioxidant found in foods such as blueberries and peanuts. The preventive properties of pterostilbene were confirmed in a study published in Cancer Prevention Research. A study published in European Urology concerning pomegranate showed its potential in supporting the treatment of prostate cancer. It was discovered that one of its components, ellagic acid, reduces chemotherapy-induced toxicity, particularly neutropenia in patients with hormone-refractory prostate disease. During the congress, it was reiterated how curcumin has a significant role in cancer prevention, acting as an antioxidant and countering the proliferation of tumor cells, inhibiting the activity of androgen receptors, and hindering their interaction with the PSA gene, leading to a decrease in hormone-dependent cells. This effectively hinders the progression of the tumor. Furthermore, curcumin targets tumor stem cells, which are crucial for the growth of the primary tumor.

Scientific rationale of the formulation

OR Prostata Prime was developed according to the modern concept of multi-target nutraceuticals, an approach that combines natural substances with complementary mechanisms of action to simultaneously address the main biological processes involved in chronic prostate inflammation, oxidative stress, lower urinary tract function, and cellular protection.

Scientific literature shows that the prostate is not affected by a single pathological mechanism, but by the interaction between chronic inflammation, alterations in androgen metabolism, oxidative damage, epigenetic changes, immune alterations, and progressive cell proliferation.

For this reason, the formulation combines highly standardized plant extracts, ensuring a consistent supply of the most extensively studied biologically active compounds.

Green tea extract (Camellia sinensis) standardized to 95% polyphenols – rich in EGCG
Epigallocatechin gallate (EGCG) is the most extensively studied catechin in green tea.
Its main biological activities include:
reduction of oxidative stress;
inhibition of the nuclear factor NF-κB;
modulation of the inflammatory response;
reduction of angiogenesis;
induction of apoptosis in altered cells;
protection of DNA from oxidative damage.
The randomized study by Bettuzzi et al. showed that men with high-grade prostatic intraepithelial neoplasia treated with green tea catechins had a significant reduction in progression to prostate cancer compared to placebo.
EGCG is also capable of interfering with the androgen receptor and numerous signaling pathways involved in prostate cell growth.
Main publications
Bettuzzi S et al. Cancer Research. 2006.
Henning SM et al. Journal of Nutrition. 2004.
Ide H et al. World Journal of Urology. 2017.
EFSA Panel on Food Additives. Safety of Green Tea Catechins. 2018.

Turmeric (Curcuma longa) standardized to 95% curcuminoids
Curcumin is one of the most extensively studied natural polyphenols in oncology.
Numerous studies demonstrate its ability to:
reduce NF-κB;
decrease TNF-α, IL-1β, and IL-6;
modulate PI3K/Akt;
inhibit mTOR;
reduce androgen receptor expression;
decrease PSA production;
inhibit epithelial-mesenchymal transition;
promote apoptosis.
Several studies also suggest an effect on prostate tumor stem cells, which are considered responsible for disease progression.
Main publications
Aggarwal BB, Harikumar KB. International Journal of Biochemistry & Cell Biology. 2009.
Kunnumakkara AB et al. Cancer Letters. 2017.
Shanmugam MK et al. Genes & Disease. 2015.

Pomegranate (Punica granatum) standardized in ellagic acid
Pomegranate is one of the main dietary sources of ellagitannins and ellagic acid.
These polyphenols exert:
powerful antioxidant activity;
reduction of lipid peroxidation;
modulation of chronic inflammation;
DNA protection;
support of the physiological immune response.
A clinical study published in Clinical Cancer Research observed a slowing of the increase in PSA in men previously treated for prostate cancer.
Further studies suggest a possible supportive role during cancer treatments due to the reduction of oxidative stress.
Main publications
Pantuck AJ et al. Clinical Cancer Research. 2006.
Paller CJ et al. Prostate Cancer and Prostatic Diseases. 2013.
Aviram M et al. American Journal of Clinical Nutrition. 2000.

Tomato lycopene
Lycopene is the carotenoid with the greatest antioxidant activity found in tomatoes.
Its main activities include:
neutralization of free radicals;
reduction of DNA damage;
modulation of cell proliferation;
regulation of intercellular communication;
protection of cell membranes.
A meta-analysis involving over 700,000 subjects highlighted an association between high lycopene intake and a reduced risk of prostate cancer, especially in more aggressive forms.
Main publications
Rowles JL et al. Nutrients. 2022.
Chen P et al. Medicine. 2015.
Giovannucci E. Journal of the National Cancer Institute. 1999.

Broccoli (Brassica oleracea) standardized in sulforaphane
Sulforaphane is one of the most important activators of the Nrf2 pathway.
The activation of this system results in:
increased endogenous antioxidant enzymes;
increased phase II detoxification;
reduction of oxidative stress;
DNA protection;
epigenetic regulation.
The Dashwood study showed that sulforaphane modulates the epigenetic enzyme SUV39H1 involved in the progression of prostate cancer.
Main publications
Dashwood RH et al. Oncogenesis. 2015.
Kensler TW et al. Annual Review of Pharmacology and Toxicology. 2013.
Fahey JW et al. Proceedings of the National Academy of Sciences. 1997.

Resveratrol (Polygonum cuspidatum)
Resveratrol is a natural stilbene with antioxidant, anti-inflammatory, antiproliferative, and anti-angiogenic activities.
It modulates numerous molecular targets:
SIRT1;
AMPK;
NF-κB;
PI3K/Akt;
mTOR.
In experimental models, it reduces the growth of prostate tumor cells and promotes apoptosis.
Main publications
Athar M et al. Toxicology and Applied Pharmacology. 2007.
Timmers S et al. Cell Metabolism. 2011.
Brasnyó P et al. British Journal of Nutrition. 2011.

Quercetin
Quercetin is one of the most extensively studied flavonoids.
In the prostate, it exerts antioxidant, anti-inflammatory, cell membrane stabilizing, and cytokine production modulating activities.
Some clinical studies have also observed an improvement in chronic prostatitis symptoms.
Main publications
Shoskes DA et al. Urology. 1999.
Li Y et al. Biomedicine & Pharmacotherapy. 2016.
Egert S et al. British Journal of Nutrition. 2009.

Reishi (Ganoderma lucidum)
Reishi polysaccharides and triterpenes are widely studied for immunomodulation, antioxidant activity, inflammation regulation, and support of innate immunity.
In experimental models, Reishi has shown the ability to inhibit 5α-reductase, an enzyme involved in the production of dihydrotestosterone (DHT), which is important in the pathophysiology of benign prostatic hyperplasia.
Main publications
Liu J et al. Journal of Nutrition. 2007.
Gao Y et al. Journal of Medicinal Food. 2003.
Sanodiya BS et al. Journal of Pharmacy and Pharmacology. 2009.

Agaricus blazei
Rich in β-glucans and bioactive polysaccharides.
It promotes:
physiological immune response;
antioxidant activity;
modulation of Natural Killer cells;
balance of the inflammatory response.
Main publications
Hetland G et al. Scandinavian Journal of Immunology. 2008.
Firenzuoli F et al. Evidence-Based Complementary and Alternative Medicine. 2008.

Eleuthero
Eleuthero is considered a natural adaptogen.
It helps to:
increase resistance to stress;
support the immune system;
improve physical and mental tone;
promote the body's physiological recovery.
Main publications
Davydov M, Krikorian AD. Journal of Ethnopharmacology. 2000.
Panossian A, Wikman G. Current Clinical Pharmacology. 2010.

Echinacea
Echinacea contributes to the maintenance of the physiological immune response through polysaccharides, alkylamides, and echinacosides.
Studies show a modulation of cytokine production and macrophage activity.
Main publications
Shah SA et al. Lancet Infectious Diseases. 2007.
Barrett B. Phytomedicine. 2003.

Bearberry
Bearberry is traditionally used to promote the physiological function of the urinary tract.
Arbutin is metabolized to hydroquinone in the urine, contributing to the maintenance of balance in the lower urinary tract.
In the formulation, it performs a complementary action to the other ingredients, promoting urinary comfort.

Main references

EMA/HMPC. Assessment Report on Arctostaphylos uva-ursi.

ESCOP Monographs. Arctostaphylos uva-ursi.

Rationale for the synergy of the formulation

The originality of OR Prostata Prime does not lie in the presence of a single ingredient, but in the synergy of standardized plant extracts that act on complementary biological mechanisms: modulation of oxidative stress (EGCG, lycopene, quercetin, resveratrol), regulation of the inflammatory response (curcumin, green tea, pomegranate), activation of endogenous antioxidant defenses through the Nrf2 pathway (sulforaphane), support of the immune response (Reishi, Agaricus blazei, Echinacea), support of the body during periods of stress (Eleuthero), and maintenance of urinary tract function (Bearberry). This multi-target strategy is consistent with the current understanding of prostate pathophysiology, in which chronic inflammation, oxidative stress, immune alterations, and changes in the cellular microenvironment interact with each other. For this reason, a combined formulation represents a more rational nutraceutical approach compared to the isolated use of individual components.

IMPORTANT WARNING Use of the product is not recommended in case of liver or biliary disorders, or gallstones in the bile ducts. Do not use during pregnancy or breastfeeding. Do not use for prolonged periods without consulting a doctor. If you are taking medication, it is advisable to consult your doctor. Do not take if you are allergic to any of its ingredients.
Food supplement. Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement or food supplement, it is important to consult your doctor or healthcare professional before use during pregnancy or breastfeeding, if you are taking medication, if you have any medical conditions or illnesses, or in view of any medical procedure. Discontinue use in case of adverse reactions and consult your doctor or healthcare professional.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace consultation with a doctor or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of food supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.