PROSTATA SAFE OPUS RURI | Prostate and Urinary Tract Supplement with Saw Palmetto, Pygeum, Cranberry and Zinc | 90 Vegetable Capsules 450 mg

Prostata Safe is specifically formulated for adult men who wish to prevent or treat age-related disorders and changes in the prostate gland.

It is the ideal ally for those who suffer from:
• Benign Prostatic Hypertrophy and Hyperplasia (BPH): for men who experience an enlarged prostate.

• Urinary tract disorders (LUTS): for those who experience a weak, intermittent urinary flow or have difficulty completely emptying the bladder.

• Nocturia and fragmented sleep: for those who are forced to wake up several times during the night due to an urgent urge, experiencing stress and daytime fatigue.

• Recurrent prostatitis: for men prone to frequent inflammation and lower urinary tract infections.

• Men concerned about reproductive health: for those who wish to protect fertility and maintain balanced hormone levels in a completely natural way.

To maximize effectiveness and ensure constant biological coverage over 24 hours, it is recommended to take 4 capsules daily (equivalent to a total intake of 1800 mg of the active blend).
• 2 capsules with lunch
• 2 capsules with dinner

Directions for use: Swallow the capsules whole with a large glass of water.

Taking them with main meals is ideal to promote the optimal absorption of the valuable fat-soluble components (such as fatty acids and phytosterols) present in the formula.

Continuous and consistent use helps consolidate the biological benefits over time.

Ingredients per daily dose 4 capsules (1800 mg):
Pygeum africanum (Prunus africana (Hook. f.) Kalkman), bark, TIT. E.S. Beta-sitosterol ≥ 2.5%, 300 mg (equivalent to 7.5 mg of Betasitosterol); Serenoa (Serenoa repens Small.), fruit, TIT. E.S. Fatty Acids ≥30%, powder, 300 mg (equivalent to 90 mg of fatty acids); Cranberry (Vaccinium macrocarpon Aiton), fruit, TIT. E.S. proanthocyanidins (PACs)≥40.0%, powder, 300 mg (equivalent to 120 mg of PACs); Beta Sitosterol (Beta Sitosterol), TIT. total sterols ≥99% (Betasitosterol 70-80%), powder, 100 mg (equivalent to 80 mg of Betasitosterol); Horse Chestnut (Aesculus hippocastanum L.), seed, TIT. E.S. Saponins 18-22%, powder, 100 mg (equivalent to 22 mg of Escin); Passionflower (Passiflora incarnata L.), flowering herb, TIT. E.S. total flavonoids≥2.5%, powder, 100 mg (equivalent to 2.5 mg of Vitexin); Nettle (Urtica dioica L.), leaf, TIT. E.S. Silica ≥2%, powder, 100 mg (equivalent to 2 mg of Silica); Lespedeza (Lespedeza capitata Michx), aerial parts, TIT. E.S. Rutin ≥4.0%, powder, 100 mg (equivalent to 4 mg of rutin); Corn Silk (Zea mays var. saccharata (Sturtev.) L.H.Bailey), stigmata, TIT. E.S. Potassium ≥4.0%, powder, 100 mg (equivalent to 4 mg of Potassium); Willowherb (Epilobium angustifolium L.), herb, E.S., powder, 100 mg; Pumpkin Seeds (Cucurbita maxima Duchesne), seeds, E.S., powder, 100 mg; Zinc (Zinc Gluconate), powder, 74 mg (equivalent to 10 mg of Zinc, 100% V.N.R.); Dog Rose (Rosa canina L.), fruit, TIT. E.S. ascorbic acid ≥70%, powder, 18 mg (equivalent to 13 mg of Vitamin C, 16% V.N.R.); Selenium (L-Selenomethionine), powder, 11 mg (equivalent to 55 µg of Selenium 100% V.N.R.);

• Benign Prostatic Hypertrophy Contrast: Blocks the main enzymatic pathways (such as 5α-reductase) responsible for the abnormal proliferation and growth of prostatic tissue.

• Optimization of Urinary Flow: Exerts a pelvic myorelaxant and decongestant action, increasing the force of the urinary stream and reducing post-void residual volume.

• Reduction of Inflammation and Pain: Deactivates local inflammatory processes, preventing episodes of acute and chronic prostatitis.

• Protection of the Urinary Tract: Hinders the adhesion of uropathogenic bacteria to the urothelial walls, drastically reducing the risk of cystitis or urethral infections.

• Fertility and Hormone Support: Actively supports normal spermatogenesis and helps maintain stable, proper testosterone levels in the blood.

• Improved Nighttime Rest: Calms bladder irritability and reduces the urge for nocturia, promoting deep mental relaxation and restorative sleep.

What is Benign Prostatic Hyperplasia and how does Prostata Safe work?
Benign Prostatic Hyperplasia (BPH) is a non-cancerous enlargement of the prostate gland, which compresses the urethra, causing a weak stream and frequent urination. Thanks to the presence of Serenoa Repens and Pygeum, Prostata Safe inhibits the 5-alpha-reductase enzyme involved in abnormal tissue growth, reducing pelvic edema and restoring the normal diameter of the urinary tract.

How long does it take to see the first results with Prostata Safe?
As it is a natural phytocomplex free of aggressive chemical molecules, the benefits manifest gradually. Most patients experience a significant improvement in urinary flow and a clear reduction in nighttime urination (nocturia) after about 3-4 weeks of regular and consistent intake of the recommended 4 daily capsules.

Does Prostata Safe have contraindications or side effects?
No, Prostata Safe was formulated by Prof. G. Mammana to ensure maximum tolerability and is completely free of significant contraindications. The absence of preservatives, industrial excipients, and chemical additives reduces the risk of intolerances to zero. It is recommended to take it on a full stomach to optimize the digestibility of the lipid extracts.

Why are Passionflower and Horse Chestnut present in the formula?
Horse Chestnut counteracts vascular congestion and improves microcirculation in the pelvic area. Passionflower, acting on the central nervous system, promotes mental relaxation. This combination relieves muscle tension in the bladder neck and alleviates anxiety related to urinary urgency, allowing for better rest at night.

Can I take Prostata Safe if I follow a vegan diet?
Absolutely. In line with Moltitudo's ethical standards, the capsule shell of Prostata Safe is made exclusively of natural cellulose plant capsules. The product is 100% vegan, free of animal gelatins or artificial colorings.

What is Prostata Safe used for?
Prostata Safe is a food supplement formulated to support the physiological function of the prostate and the health of the lower urinary tract in men. Thanks to its rich synergy of botanicals and micronutrients, it is useful for promoting regular urinary flow, supporting pelvic microcirculation, and protecting cells from the action of free radicals.

What is the correct dosage and how should it be taken?
It is recommended to take 4 capsules daily, preferably divided throughout the day or according to the instructions of your doctor/specialist, accompanied by a large glass of water.

How long does it take to notice the first benefits?
As it is a supplement based on natural extracts and micronutrients, its effectiveness manifests gradually. Generally, a continuous intake cycle of at least 4-8 weeks is recommended to fully appreciate the support of urinary and prostatic function.

What are the main ingredients of Prostata Safe?
The formula combines highly concentrated extracts such as Serenoa repens, Pygeum africanum, Beta-sitosterol, Pumpkin Seeds, Cranberry, Nettle, Epilobium, Horse Chestnut, Lespedeza, Passionflower, and Corn Silk, supplemented with essential micronutrients such as Zinc, Selenium, and Vitamin C (from Rosehip).

Does the product contain chemical additives or preservatives?
No. In full respect of the Moltitudo philosophy, the formulation is pure and essential: no preservatives, no added synthetic chemicals, and free of unnecessary additives.

Are there contraindications or interactions with medications?
Prostata Safe is well tolerated. However, in the presence of pre-existing conditions, if you are taking medications (particularly hormone therapies or anticoagulants), or if you have any doubts about your health condition, it is always advisable to consult your primary care physician or urologist before use.

Can it replace a medical therapy prescribed by a urologist?
No, food supplements are not medications and should not be considered substitutes for medical therapies or a varied and balanced diet. Prostata Safe is designed to assist and support the body's physiological processes and the general well-being of the urinary tract.

The formulation of Prostata Safe was developed using a multi-target approach aimed at supporting the physiological function of the prostate and lower urinary tract by addressing the main mechanisms involved in age-related male urinary disorders: low-grade chronic inflammation, alterations in androgen metabolism, oxidative stress, pelvic microcirculation congestion, lower urinary tract dysfunction (LUTS), and increased susceptibility to urinary tract infections.

The selection of ingredients is based on randomized clinical trials, systematic reviews, meta-analyses, EMA/HMPC monographs, and experimental evidence published in international peer-reviewed scientific journals.

Serenoa repens (Saw Palmetto)

Serenoa repens is one of the most extensively studied botanicals for the treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia (BPH). The fatty acids in the extract appear to modulate 5α-reductase activity, limiting the conversion of testosterone into dihydrotestosterone (DHT), a hormone involved in prostate tissue growth. Anti-inflammatory effects and a reduction in prostate edema have also been reported.
Several clinical trials have shown improvements in the International Prostate Symptom Score (IPSS), quality of life, nighttime urination frequency, and maximum urinary flow rate (Qmax), particularly in patients with mild or moderate symptoms.
Key clinical trials
• Wilt TJ et al. Saw Palmetto Extracts for Treatment of Benign Prostatic Hyperplasia. Cochrane Database Syst Rev. 2002.
• Tacklind J et al. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2012.
• Gerber GS et al. Randomized trial of saw palmetto in men with lower urinary tract symptoms. Urology. 2001.
• Bent S et al. Saw Palmetto for Benign Prostatic Hyperplasia. N Engl J Med. 2006.

Pygeum africanum (Prunus africana)

Pygeum africanum bark extract is traditionally used in the treatment of male urinary disorders. Evidence suggests anti-inflammatory, anti-edema, and growth factor-modulating effects involved in prostatic hyperplasia.
A Cochrane review documented improvements in nocturia, residual urinary volume, and urinary flow.
Key studies
• Ishani A et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev. 2000.
• Andro MC et al. Pygeum africanum extract for lower urinary tract symptoms. BJU International.

Beta-sitosterol

Beta-sitosterol is the phytosterol with the greatest number of clinical studies in the management of benign prostatic hyperplasia. Numerous randomized trials have shown improvements in the IPSS score, quality of life, and maximum urinary flow, as well as a reduction in post-void residual volume.
Meta-analyses confirm symptomatic benefits without significantly affecting prostate volume.
Key clinical trials
• Berges RR et al. Randomized placebo-controlled trial of β-sitosterol in benign prostatic hyperplasia. Lancet. 1995.
• Wilt TJ et al. β-Sitosterols for benign prostatic hyperplasia. BJU International. 1999.
• Klippel KF et al. Phytosterol treatment improves urinary symptoms in BPH. Br J Urol.

Pumpkin Seeds (Cucurbita maxima)

Pumpkin seed extracts are rich in phytosterols, unsaturated fatty acids, and phenolic compounds. Several clinical trials have shown improvements in urinary symptoms, quality of life, and urination frequency in patients with LUTS/BPH.
Key references
• Friederich M et al. Pumpkin seed extract in men with lower urinary tract symptoms. Urologe A.
• Cai T et al. Pumpkin seed extract and LUTS: clinical evidence. World Journal of Urology.

Cranberry (Vaccinium macrocarpon)

Proanthocyanidins (PACs) from cranberries prevent uropathogenic Escherichia coli strains from adhering to the urothelium, reducing bacterial colonization and helping maintain normal urinary tract function.
Systematic reviews confirm a reduced risk of recurrent urinary tract infections, particularly in predisposed individuals.
Key studies
• Howell AB et al. Bioactivity of cranberry proanthocyanidins against uropathogenic bacteria. Phytochemistry. 2010.
• Jepson RG et al. Cranberries for preventing urinary tract infections. Cochrane Database Syst Rev. 2023.
• Foxman B. The role of cranberry in urinary tract health. American Journal of Clinical Nutrition.
Nettle (Urtica dioica)
Nettle has been studied in combination with Serenoa repens in patients with BPH. Its bioactive compounds appear to help modulate prostate inflammation and androgen metabolism.
Key studies
• Lopatkin N et al. Combination therapy with Serenoa repens and Urtica dioica in benign prostatic hyperplasia. World Journal of Urology.
• Safarinejad MR. Urtica dioica in lower urinary tract symptoms. Journal of Herbal Pharmacotherapy.

Epilobium (Epilobium angustifolium)

Epilobium contains flavonoids, tannins, and ellagitannins with antioxidant and anti-inflammatory properties. Experimental studies have shown inhibitory effects on 5α-reductase and prostate inflammation, supporting its traditional use for prostate health.
Key references
• Stolarczyk M et al. Epilobium species in benign prostatic hyperplasia. Phytotherapy Research.
• Vitalone A et al. Herbal medicines in benign prostatic hyperplasia. Phytomedicine.
Horse Chestnut (Aesculus hippocastanum)
Escin improves venous tone and microcirculation, helping reduce pelvic congestion that may accompany certain forms of prostatic symptoms.
Key studies
• Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev.
• Sirtori CR. Aescin: pharmacology and vascular effects. Pharmacological Research.

Lespedeza capitata

Lespedeza is traditionally used to support renal drainage and the elimination of body fluids. Available evidence mainly consists of pharmacological and observational studies on improvements in urinary function and microcirculation.
Key references
• European Medicines Agency (EMA). Herbal Monographs.
• ESCOP Monographs. Lespedeza capitata.
Corn Silk (Zea mays)
Corn silk is traditionally used to promote the drainage of body fluids and urinary tract function. Experimental studies document its diuretic, antioxidant, and soothing effects on the urinary epithelium.
Key references
• Velazquez DVO et al. Pharmacological effects of corn silk. Journal of Ethnopharmacology.
• Hasanudin K et al. Corn silk as functional food and medicinal plant. Molecules.

Passionflower (Passiflora incarnata)

Passionflower is documented for its anxiolytic and relaxing properties. In patients with LUTS and nocturia, improved sleep quality may indirectly contribute to a greater perception of well-being and quality of life.
Key studies
• Miyasaka LS et al. Passiflora incarnata in anxiety disorders. Phytotherapy Research.
• Sarris J et al. Herbal medicines for psychiatric disorders. CNS Drugs.

Zinc

Zinc is highly concentrated in the prostate and plays a key role in protecting against oxidative stress, supporting immune function, and maintaining normal blood testosterone levels, as recognized by authorized European Union health claims.
Key references
• Costello LC, Franklin RB. The role of zinc in the prostate. Molecular Cancer.
• EFSA NDA Panel. Scientific Opinion on Zinc Health Claims. EFSA Journal.

Selenium

Selenium is an essential cofactor for glutathione peroxidase and other antioxidant enzymes involved in protecting cells from oxidative stress. Numerous epidemiological studies have assessed its role in prostate health.
Key references
• Rayman MP. The importance of selenium to human health. Lancet.
• Vinceti M et al. Selenium and prostate health. Nutrients.
• EFSA NDA Panel. Scientific Opinion on Selenium Health Claims.

Vitamin C (Rosa canina)

Vitamin C helps protect cells from oxidative stress, supports the normal functioning of the immune system, and regenerates oxidized vitamin E, supporting the formulation's antioxidant network.
Key references
• Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017.
• Padayatty SJ et al. Vitamin C as an antioxidant. Journal of the American College of Nutrition.
General bibliography
• Wilt TJ et al. Saw Palmetto for Benign Prostatic Hyperplasia. Cochrane Database of Systematic Reviews.
• Tacklind J et al. Serenoa repens for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews.
• Ishani A et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database of Systematic Reviews.
• Berges RR et al. Randomized placebo-controlled trial of β-sitosterol in benign prostatic hyperplasia. Lancet. 1995.
• Howell AB et al. Bioactivity of cranberry proanthocyanidins against uropathogenic bacteria. Phytochemistry. 2010.
• Jepson RG et al. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2023.
• Lopatkin N et al. Combination therapy with Serenoa repens and Urtica dioica in benign prostatic hyperplasia. World Journal of Urology.
• Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database of Systematic Reviews.
• Costello LC, Franklin RB. Zinc and the prostate. Molecular Cancer.
• Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017.
• Rayman MP. Selenium and human health. The Lancet.
• EFSA NDA Panel. Scientific Opinions on Zinc, Selenium and Vitamin C Health Claims. EFSA Journal.

Food supplement. Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement or food supplement, it is important to consult your doctor or therapist before use during pregnancy or breastfeeding, when taking medication, in case of various illnesses or medical conditions, or prior to any medical procedure. Discontinue use in case of adverse reactions and consult your doctor or therapist.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace consultation with a doctor or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of food supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.