DIMALOE OPUS RURI | Natural Support for Fat and Sugar Metabolism | 90 Vegetable Capsules 450 mg

Dimaloe is intended for adults who wish to:
• support carbohydrate and lipid metabolism;
• control hunger during a nutritional program;
• help maintain body weight alongside a balanced diet and physical activity;
• supplement with nutrients with antioxidant properties;
• support energy metabolism during periods of increased demand;
• complement programs dedicated to metabolic well-being.

It is recommended to take 2 capsules at lunch and 2 at dinner.

Garcinia cambogia, Gymnema sylvestre, Green Coffee, Maitake, Griffonia simplicifolia, Dog Rose, Vitamin E, Long pepper (Piper longum), Vegetable capsule.

Formulation without preservatives, without added chemicals and without unnecessary additives.

Content per daily dose (4 capsules 1800 mg)
Garcinia Cambogia (Garcinia cambogia), fruit, TIT. E.S. Hydroxycitric Acid≥60%, powder, 833 mg (equivalent to 500 mg of Hydroxycitric Acid);
Gymnema (Gymnemasylvestre R. Brown), leaf, TIT. E.S. gymnemic acids≥25%, powder 400 mg (equivalent to 100 mg of Gymnemic Acids);
Green Coffee (Coffea arabica L.). Seed. TIT. E.S. Chlorogenic AC.≥45%, powder, 222 mg (equivalent to 100 mg of Chlorogenic Acid and 4 mg of caffeine);
Maitake (Grifola frondosa Gray), fruiting body, TIT. E.S. Polysaccharides ≥20%, powder 108 mg (equivalent to 21.6 mg of polysaccharides);
Griffonia (Griffoniasimplicifolia (DC) Baill.), seed, TIT. E.S. 5HTP ≥20.0%, powder, 150 mg (equivalent to 30 mg of 5-hydroxytryptophan);
Dog Rose (Rosa canina L.), fruit, TIT. E.S. L-ascorbic acid ≥70%, powder, 51 mg (equivalent to 35 mg of ascorbic acid, 43 % V.N.R.);
Vitamin E(DL-Alpha-Tocopheryl Acetate), TIT. ≥50%, powder, 18 mg (equivalent to 9 mg of vitamin E, 75 % V.N.R.);
Pepper (Piper Longum), fruit, TIT. E.S. Piperine ≥90 %, powder, 18 mg (equivalent to 16.2 mg of Piperine);
Vegetable capsule

Garcinia cambogia contributes to body weight control and the balance of lipid metabolism.

Gymnema supports carbohydrate metabolism and contributes to hunger control.

Green Coffee naturally provides chlorogenic acids useful in a formulation dedicated to energy metabolism.

Griffonia provides 5-hydroxytryptophan (5-HTP), a serotonin precursor.

Maitake provides polysaccharides naturally present in the mushroom.

Vitamin C contributes:
• to normal energy metabolism;
• to the normal function of the immune system;
• to the protection of cells from oxidative stress.
Vitamin E contributes to the protection of cells from oxidative stress.

Piperine promotes the bioavailability of the formulation's components.

What is Dimaloe used for?
Dimaloe is a natural supplement formulated to support carbohydrate and lipid metabolism, promote appetite control, and provide nutrients with antioxidant activity.

Does Dimaloe aid metabolism?
The formulation contains Garcinia cambogia, Gymnema, and Green Coffee, ingredients traditionally used to support energy metabolism and weight control as part of a balanced diet.

Does Dimaloe contain caffeine?
Yes. The presence of Green Coffee provides approximately 4 mg of caffeine per daily dose, a very small amount.

Is it suitable for a low-calorie diet?
It can provide valuable nutritional support as part of a controlled diet combined with physical activity.

Does Dimaloe contain ingredients of animal origin?
No. The product uses vegetable capsules and is formulated with ingredients of plant origin.

How long does one package last?
One package contains 90 capsules. At the recommended dose of 4 capsules per day, it provides approximately 22 days of treatment.

When should Dimaloe be taken?
It is recommended to take the capsules during the day, preferably with main meals.

The Dimaloe formulation was developed to provide nutritional support for body weight control, carbohydrate and lipid metabolism, appetite modulation, and protection against oxidative stress.

The selection of ingredients is supported by clinical studies, systematic reviews, and consensus documents describing their mechanisms of action and safety of use.

Garcinia cambogia (Hydroxycitric Acid - HCA)

Hydroxycitric acid (HCA) is the main bioactive constituent of Garcinia cambogia and has been extensively studied for its role in lipid metabolism and appetite control. The proposed mechanism consists in the inhibition of the ATP-citrate lyase enzyme, involved in fatty acid synthesis, with a possible reduction in lipogenesis and modulation of satiety through the regulation of serotonergic metabolism.

Systematic reviews show modest but statistically significant effects on body weight reduction, especially when associated with a low-calorie diet and physical activity.

Main clinical studies

Onakpoya I, Hung SK, Perry R, Wider B, Ernst E. The use of Garcinia extract (Hydroxycitric Acid) as a weight loss supplement: a systematic review and meta-analysis. Journal of Obesity. 2011.
Heymsfield SB et al. Garcinia cambogia (Hydroxycitric Acid) as a potential anti-obesity agent. JAMA. 1998.
Chuah LO et al. Updates on anti-obesity effect of Garcinia origin (-)-HCA. Evidence-Based Complementary and Alternative Medicine. 2013.
Preuss HG et al. Effects of Garcinia cambogia extract on body weight and lipid metabolism. Nutrition Research. 2004.
Gymnema sylvestre

Gymnema sylvestre is one of the most studied plants in the support of carbohydrate metabolism. Gymnemic acids reduce intestinal glucose absorption, modulate the perception of sweet taste, and can contribute to the maintenance of the physiological functionality of pancreatic beta cells.

The available evidence shows improvements in glycemic control, insulin sensitivity, and glycated hemoglobin in subjects with carbohydrate metabolism alterations.

Main studies

Baskaran K et al. Antidiabetic effect of Gymnema sylvestre in non-insulin dependent diabetes mellitus. Journal of Ethnopharmacology. 1990.
Shanmugasundaram ERB et al. Use of Gymnema sylvestre leaf extract in diabetes mellitus. Journal of Ethnopharmacology. 1983.
Leach MJ. Gymnema sylvestre for diabetes mellitus. Nutrition Research. 2007.
Tiwari P et al. Gymnema sylvestre: a review of pharmacological properties. Journal of Dietary Supplements. 2014.
Green Coffee (Chlorogenic Acid)

The chlorogenic acids of green coffee have been the subject of numerous studies regarding postprandial glycemic control, insulin sensitivity, and energy metabolism. The low caffeine content of the formulation reduces the risk of stimulating effects while maintaining the intake of polyphenols.

Main studies

Vinson JA et al. Randomized double-blind placebo-controlled study of green coffee extract in overweight subjects. Diabetes Metabolic Syndrome and Obesity. 2012.
Onakpoya I et al. The use of green coffee extract as a weight loss supplement: systematic review. Gastroenterology Research and Practice. 2011.
Meng S et al. Effects of chlorogenic acid on glucose metabolism. Food and Chemical Toxicology. 2013.
Tajik N et al. Chlorogenic Acid and Health: A Review. Journal of Evidence-Based Complementary & Alternative Medicine. 2017.
Maitake (Grifola frondosa)

Maitake contains β-glucans and bioactive polysaccharides with immunomodulating and metabolic activity. Several studies suggest an improvement in insulin sensitivity and carbohydrate metabolism in subjects with metabolic syndrome.

Main studies

Preuss HG et al. Maitake mushroom extracts improve insulin sensitivity. Molecular and Cellular Biochemistry. 2002.
Kubo K et al. Antidiabetic activity of Maitake mushroom fractions. Journal of Nutrition. 1994.
Mayell M. Maitake extracts and metabolic syndrome. Alternative Medicine Review. 2001.
Chen JT et al. Grifola frondosa polysaccharides and metabolic health. International Journal of Medicinal Mushrooms. 2013.
Griffonia simplicifolia (5-HTP)

5-hydroxytryptophan represents the direct precursor of serotonin and has been studied mainly for the control of emotional hunger, satiety, and mood tone, aspects frequently involved in weight control programs.

Main studies

Cangiano C et al. Eating behavior and adherence to dietary prescriptions in obese adults treated with 5-HTP. American Journal of Clinical Nutrition. 1992.
Ceci F et al. 5-Hydroxytryptophan in obesity treatment. Journal of Neural Transmission. 1989.
Shaw K et al. Tryptophan and 5-HTP for depression. Cochrane Database of Systematic Reviews. 2002.
Rondanelli M et al. Role of serotonin precursors in appetite regulation. Nutrients. 2021.
Hawthorn (Natural Vitamin C)

Vitamin C physiologically contributes to energy metabolism, the reduction of oxidative stress, and cellular protection. Hawthorn extract provides natural vitamin C along with polyphenols and carotenoids.

Main studies

Pullar JM et al. The Roles of Vitamin C in Skin Health and Oxidative Stress. Nutrients. 2017.
Carr AC, Maggini S. Vitamin C and Immune Function. Nutrients. 2017.
Lykkesfeldt J. Vitamin C in chronic disease prevention. Nutrients. 2020.
Vitamin E

Vitamin E represents the main fat-soluble antioxidant of the body and protects cell membranes from lipid peroxidation, a phenomenon particularly relevant in subjects with overweight, obesity, and metabolic syndrome.

Main studies

Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radical Biology & Medicine. 2007.
Brigelius-Flohé R, Traber MG. Vitamin E: Function and metabolism. FASEB Journal. 1999.
Rizvi S et al. The role of vitamin E in human health. Journal of Clinical Biochemistry and Nutrition. 2014.
Piperine (Piper longum)

Piperine improves the bioavailability of numerous phytochemical compounds through the modulation of intestinal and hepatic metabolic enzymes and promotes the absorption of bioactive substances present in the formulation.

Main studies

Shoba G et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Medica. 1998.
Srinivasan K. Black pepper and its pungent principle piperine: a review. Critical Reviews in Food Science and Nutrition. 2007.
Meghwal M, Goswami TK. Piperine: chemistry and pharmacological properties. Open Access Scientific Reports. 2013.
Systematic reviews and studies on the nutritional treatment of overweight, obesity, and metabolic syndrome
Jensen MD et al. 2013 AHA/ACC/TOS Guideline for the Management of Overweight and Obesity in Adults. Circulation. 2014.
Garvey WT et al. American Association of Clinical Endocrinology Clinical Practice Guidelines for Obesity. Endocrine Practice. 2016.
Bray GA, Ryan DH. Medical Therapy for the Patient with Obesity. Circulation. 2012.
Astrup A, Rössner S, Van Gaal L et al. Effects of lifestyle and nutritional interventions in obesity management. International Journal of Obesity. 2015.
Institutional sources and regulatory references
EFSA NDA Panel. Scientific Opinions on Dietary Reference Values and health claims for Vitamin C and Vitamin E.
EFSA Journal. Safety assessment of hydroxycitric acid (Garcinia cambogia).
Regulation (EC) No. 1924/2006 on nutrition and health claims.
Regulation (EU) No. 432/2012 laying down a list of permitted health claims.
Regulation (EU) No. 1169/2011 on the provision of food information to consumers.
Directive 2002/46/EC on food supplements.
Ministry of Health guidelines on food supplements and plant substances and preparations (latest available revision).
ESCOP Monographs (latest edition).
EMA/HMPC European Medicines Agency – Community Herbal Monographs for Gymnema sylvestre, Piper spp. and botanicals of nutraceutical interest.

Food supplement. Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement or food supplement, it is important to consult your doctor or therapist before use during pregnancy, breastfeeding, when taking medication, in case of various illnesses or medical conditions, or in view of any kind of medical procedure. Discontinue use in case of adverse reactions and consult your doctor or therapist.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace the doctor-patient relationship or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of dietary supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Dietary supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.