MOLTITUDO® PURISIA | for urinary tract infections, cystitis and recurrent cystitis | 30 capsules 400 mg | D-Mannose, Birch, Cranberry

MOLTITUDO® PURISIA is designed for those seeking targeted nutritional support to:

• maintain the normal well-being of the urinary tract;

• support the drainage of body fluids;

• support urinary comfort during periods of increased sensitivity;

• help maintain the balance of the urinary environment;

• complement a lifestyle focused on urinary tract well-being;

• support the management of oxidative stress and low-grade inflammation that may accompany conditions involving urothelial vulnerability.

PURISIA is dedicated to those who wish to carefully preserve the well-being and regularity of their lower urinary tract.

It is intended for women and men experiencing recurrent or occasional bladder-related discomfort who wish to break the cycle of urothelial recurrences.

It is designed for those seeking clean, effective daily protection aimed at supporting the normal integrity of the glycosaminoglycan (GAG) layer and preventing alterations in tissue permeability.

It is ideal for anyone who requires the transparency and biocompatibility of a formulation strictly free from unnecessary additives, featuring highly purified botanical extracts with excellent long-term tolerability.

Daily support: 1 capsule daily.
During times of greater need: up to 4 capsules daily, preferably one capsule every 3 hours.

Ingredients per daily dose (4 capsules)
D-Mannose — 1000 mg
Cranberry (Vaccinium macrocarpon) dry extract — 300 mg, of which Proanthocyanidins (PAC) — 120 mg
Birch (Betula pubescens) dry extract — 300 mg
Hibiscus (Hibiscus sabdariffa) dry extract — 200 mg

Ingredients per daily dose (1600 mg) four capsules:

D-Mannose (from Roth’s silver birch), powder, 1000 mg;
Cranberry (Vaccinium macrocarpon Aiton), fruit, standardized extract in proanthocyanidins (PACs) ≥40.0%, powder 300 mg (equivalent to 120 mg of PACs);
Downy birch (Betula pubescens Ehrh), leaf, standardized extract in total flavonoids 2.0%-3.0%, powder, 200 mg (equivalent to 6 mg of hyperoside);
Hibiscus (Hibiscus sabdariffa L), flowers, extract, powder, 100 mg;
vegetable capsule.

Through a multimodal and synergistic approach, MOLTITUDO® PURISIA acts on multiple biological levels.

Its superior anti-adhesion action mechanically prevents pathogenic bacteria from attaching to the urothelial walls through the competitive binding of D-Mannose and type A proanthocyanidins (PACs) from Cranberry.

The phytocomplex ensures constant functional flushing and cleansing that promotes increased urinary flow through Birch flavonoids, facilitating the dilution and expulsion of microbial sediments and inflammatory mediators.

The modulation of the urinary microenvironment is supported by Hibiscus extract, which provides organic acids capable of maintaining a urinary pH unfavorable to microbial proliferation and virulence.

Finally, the formula offers deep protection and optimal tissue comfort, supporting natural epithelial defenses, reducing submucosal irritative stimuli, and counteracting residual inflammation.

Purisia was created to support the physiological well-being of the urinary tract through an essential approach focused on the body's balance.

Useful as nutritional support during periods of increased urinary tract sensitivity, including in cases of urinary tract infections, cystitis, and recurrent cystitis.

Nutritional support for daily urinary comfort.
Support for maintaining the physiological balance of the urinary environment.

Formula designed to easily integrate into your daily routine.

Natural approach without preservatives, unnecessary additives, or superfluous substances.

Essential composition focused on ingredient quality.

Suitable for those seeking nutritional support as part of a comprehensive wellness journey.

What is Purisia used for?
Purisia is a supplement formulated to support the physiological well-being of the urinary tract and help maintain the natural balance of the urinary environment.

Can it be useful for urinary tract infections, cystitis, or recurrent cystitis?
Purisia can be used as nutritional support during periods when the urinary tract is particularly sensitive, including in cases of urinary tract infections, cystitis, and recurrent cystitis.

When should Purisia be taken?
1 capsule daily in the morning, or if needed, 4 capsules daily, preferably one every 3 hours from morning to evening.
Can Purisia be incorporated into a daily routine?
Yes, the formulation is designed for practical use and can easily be incorporated into daily habits.

Does Purisia contain preservatives or unnecessary ingredients?
No. The formulation follows an approach focused on simplicity and the careful selection of ingredients.

How long can it be used?
The duration of use may vary depending on individual needs and the guidance of a healthcare professional, but there are no restrictions on continuous use.

What is D-Mannose and how does it work in Moltitudo Purisia?
D-Mannose is a naturally occurring monosaccharide extracted in pure form from birch bark. Once taken orally, it is excreted unchanged by the kidneys and reaches the bladder. In this microenvironment, it competitively binds to the tips of the fimbriae of Escherichia coli bacteria, preventing them from attaching to the bladder mucosa. The pathogens thus remain suspended and are mechanically flushed out with the normal flow of urine.

Can I use Purisia in combination with antibiotic therapy?
Moltitudo Purisia does not interfere with the action of common antibiotics and serves as an excellent complementary support. While the medication works to reduce the bacterial load, the natural components of Purisia hinder the recolonization of residual strains and promote protective mechanical flushing of the urothelium.

Why is the formulation free from preservatives and chemical additives?
True to Moltitudo's philosophy of purity, the formula completely excludes unnecessary synthetic excipients or technological additives such as magnesium stearate or silicon dioxide. This approach avoids unnecessary irritative overload on the body, ensuring maximum tolerability of the plant-based phytocomplexes and full respect for tissue biocompatibility.

How long does it take to notice the first benefits? During periods of greater intimate stress, intensive intake of up to four capsules allows for a deep urothelial flush that can be noticed within the first twenty-four or forty-eight hours. For recurring discomfort, a continuous maintenance cycle of at least four to six weeks is recommended to support the stability and repair of natural barriers.

The formulation of Purisia Moltitudo was developed to physiologically support the urinary tract and help prevent recurrent urinary tract infections (rUTIs), particularly uncomplicated cystitis.

The combination of D-mannose, standardized cranberry extract rich in A-type proanthocyanidins (PAC-A), birch, and hibiscus sabdariffa extract is based on complementary mechanisms of action, including the inhibition of bacterial adhesion to the urothelium, support for the physiological flushing of the urinary tract, modulation of the urinary environment, and control of the local inflammatory response.

The formulation provides 1000 mg of D-mannose, 300 mg of cranberry standardized to 40% PAC (120 mg PAC), 200 mg of birch, and 100 mg of hibiscus sabdariffa per daily dose.

D-mannose and the prevention of recurrent urinary tract infections
D-mannose is currently one of the most extensively studied natural active ingredients for preventing recurrent cystitis. Its mechanism involves competitively binding to the FimH lectin found on the type 1 fimbriae of uropathogenic Escherichia coli, preventing the bacteria from adhering to the urothelium and promoting their elimination through urination. This mechanism does not exert selective pressure on bacteria or promote the development of antibiotic resistance.
Key clinical studies
• Kranjčec B, Papeš D, Altarac S. D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology. 2014.
• Porru D, Parmigiani A, Tinelli C, et al. Oral D-mannose in recurrent urinary tract infections. Journal of Clinical Urology. 2014.
• Lenger SM, Bradley MS, Thomas DA, et al. D-mannose vs. other agents for recurrent urinary tract infection prevention. American Journal of Obstetrics & Gynecology. 2020.
• Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nature Reviews Microbiology. 2015.
• Wellens A, Garofalo C, Nguyen H, et al. Intervening with urinary tract infections using the FimH-mannose interaction. PLoS One. 2008.

Cranberry (Vaccinium macrocarpon) and recurrent cystitis
The A-type proanthocyanidins (PAC-A) in cranberry interfere with the P-fimbriae of Escherichia coli, reducing bacterial adhesion, biofilm formation, and colonization of the urinary mucosa. Numerous meta-analyses confirm a reduction in the frequency of recurrences, particularly in women with rUTIs.
Key clinical studies and reviews
• Jepson RG, Williams G, Craig JC. Cranberries for preventing urinary tract infections. Cochrane Database of Systematic Reviews. 2023.
• Fu Z, Liska D, Talan D, Chung M. Cranberry reduces the risk of urinary tract infection recurrence in otherwise healthy women. Journal of Nutrition. 2017.
• Wang CH, Fang CC, Chen NC, et al. Cranberry-containing products for prevention of urinary tract infections. Archives of Internal Medicine. 2012.
• Maki KC, Kaspar KL, Khoo C, et al. Consumption of a cranberry beverage lowered the number of clinical urinary tract infection episodes. American Journal of Clinical Nutrition. 2016.
• Howell AB, Reed JD, Krueger CG, et al. A-type cranberry proanthocyanidins and urinary tract health. Critical Reviews in Food Science and Nutrition. 2010.
• Foo LY, Lu Y, Howell AB, Vorsa N. A-type proanthocyanidins from cranberry inhibit adhesion of uropathogenic Escherichia coli. Journal of Natural Products. 2000.

Birch (Betula pubescens)
Birch is traditionally used as a diuretic. A physiological increase in urine flow promotes the flushing of the urinary tract, reduces urinary stasis, and helps eliminate microorganisms and inflammatory mediators. Its flavonoids and triterpenes have also been shown to have anti-inflammatory activity in experimental studies.
Monographs and scientific literature
• European Medicines Agency (EMA-HMPC). Community Herbal Monograph on Betula folium.
• European Medicines Agency. Assessment Report on Betula pendula Roth and Betula pubescens Ehrh. folium. EMA/HMPC. 2014.
• ESCOP Monographs. Betulae folium.
• Shikov AN, Pozharitskaya ON, Makarov VG, Wagner H. Betula species in traditional medicine and current pharmacological research. Phytotherapy Research. 2014.
• Wichtl M. Herbal Drugs and Phytopharmaceuticals.

Hibiscus sabdariffa
Hibiscus sabdariffa extracts are rich in anthocyanins, flavonoids, and organic acids. The literature highlights their antimicrobial, anti-biofilm, antioxidant, and diuretic activities, as well as their ability to help create a urinary environment that is less conducive to bacterial proliferation.
Key studies
• Da-Costa-Rocha I, Bonnlaender B, Sievers H, et al. Hibiscus sabdariffa L.: A phytochemical and pharmacological review. Food Chemistry. 2014.
• Ali BH, Wabel NA, Blunden G. Phytochemical, pharmacological and toxicological aspects of Hibiscus sabdariffa. Phytotherapy Research.
• Cowdrey L, et al. Hibiscus sabdariffa extracts inhibit bacterial growth and biofilm formation. BMC Complementary and Alternative Medicine. 2015.
• Mahadevan N, Shivali. Hibiscus sabdariffa Linn – An overview. Natural Product Radiance. 2009.

Clinical evidence for the combination formulation
The combination of D-mannose + cranberry + birch + hibiscus sabdariffa simultaneously addresses the main pathophysiological mechanisms of cystitis:
• reduction of Escherichia coli adhesion to the urothelium;
• reduction of bacterial biofilm formation;
• increased physiological flushing of the urinary tract;
• support for maintaining a urinary environment that is less conducive to bacterial proliferation;
• modulation of the local inflammatory response;
• reduction in the risk of recurrences without promoting antibiotic resistance.
Studies on the combination of ingredients
• Vicariotto F. Cranberry extract, D-mannose and Lactobacilli in women with recurrent cystitis. Journal of Clinical Gastroenterology. 2014.
• Koradia P, Kapadia S, Trivedi Y, et al. Probiotic and cranberry supplementation in urinary tract infections. Expert Review of Anti-Infective Therapy. 2019.

Main conditions supported by the literature for the use of Purisia ingredients
The available scientific evidence supports the use of the ingredients in Purisia Moltitudo as nutritional support for:
• recurrent urinary tract infections (rUTIs);
• uncomplicated acute cystitis (as complementary support to medical therapy);
• prevention of recurrences in predisposed women;
• mild urinary symptoms (burning, frequency, urgency);
• support for the physiological function of the urinary tract;
• strategies to reduce the repeated use of antibiotics (antibiotic stewardship) in recurrences, as assessed by the treating physician.

Additional supporting bibliography:

Chou, H. I., Chen, K. S., Wang, H. C., et al. (2016). Effects of Hibiscus sabdariffa L. extract on prevention of recurrent urinary tract infections. Journal of Functional Foods, 22, 451-458.

Howell, A. B., Botto, H., Combescure, C., et al. (2010). Dosage effect of cranberry proanthocyanidins on bacterial adhesion: a randomized, double-blind, placebo-controlled trial. BMC Infectious Diseases, 10, 94.

Kranjčec, B., Papeš, D., & Altarac, S. (2014). D-mannose powder for prophylaxis of recurrent urinary tract infections in women: a randomized clinical trial. World Journal of Urology, 32(1), 79-84.
Liska, D. J., Kern, H. J., & Maki, K. C. (2016).

Cranberry and Urinary Tract Health: Science-Based Evidence for Product Claims. Molecular Nutrition & Food Research, 60(12), 2580-2592.

Parsons, C. L. (2007). The role of a leaky epithelium and potassium in the pathogenesis of interstitial cystitis. BJU International, 100 Suppl 1, 6-11.

Food supplement - Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement or food supplement, it is important to consult your doctor or therapist before use during pregnancy or breastfeeding, when taking medication, in case of various illnesses or medical conditions, or in view of any kind of medical procedure. Discontinue use in case of adverse reactions and consult your doctor or therapist.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace the doctor-patient relationship or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of dietary supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Dietary supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.