CISTALOE OPUS RURI | Cranberry, Turmeric and 5 Highly Viable Probiotics for the Urinary Tract and Intestinal Microbiota| 60 capsules 450 mg

Cistaloe is designed for men and women who wish to physiologically support urinary tract health and the balance of the intestinal microbiota through a scientifically sound natural supplement.

It is particularly suitable for those prone to recurrent episodes of urinary discomfort.

Numerous clinical studies and systematic reviews have shown that type A proanthocyanidins from cranberry can help reduce the ability of uropathogenic Escherichia coli to adhere to the urothelium, a biological mechanism involved in recurrent urinary tract infections.

It can provide valuable support for those with alterations in the intestinal microbiota due to periods of stress, poor diet, or previous antibiotic treatments.

The selected probiotic strains belong to the species most extensively studied in the scientific literature for maintaining the balance of the intestinal flora.

It is also suitable for people who wish to support the balance of the uro-genital microbiota, now recognized as one of the main factors involved in maintaining the physiological function of the lower urinary tract.

The presence of turmeric makes the formulation also suitable for those who wish to increase their intake of polyphenols with antioxidant activity and support the body's physiological inflammatory response processes.

The combination of cranberry and probiotics is supported by numerous clinical studies that have shown how rebalancing the microbiota can help maintain urinary health, especially in individuals prone to recurrence.

It can also be taken even in the absence of any issues, as it is a concentrate of natural substances beneficial to our body.

Those recovering from debilitating illnesses or following antibiotic therapy.

Those who have gastrointestinal disorders, fatigue, difficulty concentrating, insomnia, indigestion, nervous hunger, muscle pain, nervousness, and anxiety;
which merge into a general sense of malaise that makes days more difficult

Those who do not have such disorders but want to prevent them.

Shock therapy: 2 capsules if needed
Maintenance: 1 capsule daily

Ingredients: Cranberry, Turmeric, Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Saccharomyces boulardii, Bacillus coagulans, vegetable capsule.
Cistaloe is formulated exclusively with ingredients carefully selected for their quality and purity.

The formulation is made in a vegetable capsule and is free from preservatives, contains no added chemicals and no unnecessary additives. The plant extracts are standardized to ensure a consistent content of active ingredients, while the probiotic strains are selected for their high viability and stability, ensuring a significant supply of live microorganisms until the end of the product's shelf life.

Daily dose: 2 capsules (900 mg)
Cranberry (Vaccinium macrocarpon Aiton), fruit, dry extract standardized to proanthocyanidins (PAC) ≥40% — 200 mg, equivalent to 80 mg of PAC
Turmeric (Curcuma longa L.), rhizome, dry extract standardized to curcuminoids ≥95% — 200 mg, equivalent to 190 mg of curcuminoids
Lactobacillus acidophilus — 20 billion live microorganisms
Lactobacillus plantarum — 10 billion live microorganisms
Lactobacillus rhamnosus — 10 billion live microorganisms
Saccharomyces boulardii — 1 billion live microorganisms
Bacillus coagulans — 700 million live microorganisms
Vegetable capsule.

Ingredients per daily dose (900 mg) two capsules
Cranberry (Vaccinium macrocarpon Aiton), fruit, EXT. STAND. proanthocyanidins (PACs) ≥40.0%, powder 200 mg (equivalent to 80 mg of PACs);
Turmeric (Curcuma Longa L.) rhizome EXT. STAND. curcuminoids ≥95% powder 200 mg (equivalent to 190 mg of curcuminoids);
Lactobacillus Acidophilus, ≥100*109 CFU/g, freeze-dried powder, 200 mg (20 billion live microorganisms);
Lactobacillus Plantarum, ≥100*109 CFU/g, freeze-dried powder, 100 mg (10 billion live microorganisms);
Lactobacillus Rhamnosus, ≥100*109 CFU/g, freeze-dried powder, 100 mg (10 billion live microorganisms);
Saccharomyces boulardii, ≥20*109 CFU/g, freeze-dried powder, 50 mg (1 billion live microorganisms);
Bacillus coagulans, ≥15 *109 CFU/g, freeze-dried powder, 50 mg (700 million live microorganisms);

The Cistaloe formulation was developed to provide comprehensive physiological support thanks to the complementary nature of its ingredients.
Standardized cranberry provides 80 mg of type A proanthocyanidins (PAC), an amount consistent with numerous clinical studies that have shown a reduction in the adhesion of uropathogenic bacteria to the urinary tract epithelium.

The five probiotic strains help maintain the balance of the intestinal bacterial flora, promoting a diverse and functional microbiota, which is now recognized as also important for the well-being of the urogenital tract.

The simultaneous presence of Lactobacillus acidophilus, Lactobacillus plantarum, and Lactobacillus rhamnosus helps support different compartments of the microbiota thanks to their functional complementarity documented in the scientific literature.

Saccharomyces boulardii helps maintain the balance of the intestinal microbiota even during situations that can alter the resident flora, while Bacillus coagulans ensures high stability during gastrointestinal transit thanks to its natural ability to form spores.

The highly concentrated turmeric extract provides curcuminoids with antioxidant activity and helps maintain normal digestive function and physiological inflammatory response processes.

The entire formulation works according to an integrated approach that considers the well-being of the urinary tract, intestinal balance, the mucosal barrier, and protection from oxidative stress as closely linked elements.

The formulation is free from preservatives, added chemicals, and unnecessary additives, and is enclosed in easily swallowed plant-based capsules.

What is Cistaloe used for?
Cistaloe is a food supplement designed to support the physiological well-being of the urinary tract and promote a balanced intestinal microbiota through a combination of high-PAC cranberry, turmeric, and five selected probiotic strains.

Is Cistaloe indicated for recurrent cystitis?
Cranberry is one of the most extensively studied ingredients for maintaining urinary tract function. Numerous clinical studies have shown that type A proanthocyanidins (PACs) can reduce the adhesion of Escherichia coli to the urinary epithelium, a mechanism involved in recurrent urinary tract infections. Cistaloe is a food supplement and does not replace medical treatments prescribed by a doctor.

Why does Cistaloe contain probiotics?
Recent research shows that the intestinal microbiota is one of the main reservoirs of bacteria involved in urinary tract infections. Promoting a balanced intestinal flora can help maintain the physiological well-being of the urogenital system.

How many lactic acid bacteria are in a daily dose?
The daily dose provides over 41 billion live microorganisms from five different probiotic species: Lactobacillus acidophilus, Lactobacillus plantarum, Lactobacillus rhamnosus, Saccharomyces boulardii, and Bacillus coagulans.

Why does it contain turmeric?
Turmeric provides highly pure curcuminoids, naturally occurring compounds rich in antioxidant activity that help maintain digestive function and support the body's natural inflammatory response processes.

What is the benefit of the 80 mg of PACs from cranberry?
Clinical studies have shown that doses of type A proanthocyanidins between 36 and 80 mg are the most commonly used amounts for supporting urinary tract function. The 80 mg in Cistaloe is at the upper end of the most studied doses.

Can Cistaloe be taken after a course of antibiotics?
The inclusion of selected probiotics makes the formulation particularly suitable for the periods following treatments that may alter the balance of the intestinal microbiota. For specific treatments, however, it is advisable to follow your doctor's advice.

How long is it recommended to take Cistaloe?
Available studies on the main ingredients generally evaluated periods of use between four and twelve weeks. The duration of supplementation can be tailored to individual needs and based on the advice of a healthcare professional.

Does Cistaloe contain preservatives or additives?
No. The formulation is made without preservatives, without added chemicals, and without unnecessary additives. The capsules are exclusively plant-based.

Who can take Cistaloe?
It is suitable for adult men and women who wish to support urinary tract well-being, promote a balanced intestinal microbiota, and increase their intake of natural substances with antioxidant activity.

Can Cistaloe be taken every day?
At the recommended doses, the ingredients have a favorable safety profile documented by scientific literature and are suitable for daily use according to the directions on the label.

Does Cistaloe replace medication?
No. Cistaloe is a food supplement intended to supplement the diet and support the body's normal physiological functions. It is not a medicine and does not replace any treatments prescribed by a doctor.

Cranberry (Vaccinium macrocarpon)
Fu Z, Liska D, Talan D, Chung M. Cranberry reduces the risk of urinary tract infection recurrence in otherwise healthy women: a systematic review and meta-analysis. Journal of Nutrition. 2023.
European Association of Urology (EAU). Guidelines on Urological Infections. Updated edition 2025.
Howell AB, Botto H, Combescure C, Blanc-Potard AB, Gausa L, Matsumoto T. Dosage of type A proanthocyanidins and anti-adhesion activity against uropathogenic Escherichia coli. Clinical and experimental studies.
Liska DJ, Kern HJ, Maki KC. Cranberry and urinary tract health: clinical evidence and future perspectives. Nutrition Reviews. 2024.

Curcuma longa
Hewlings SJ, Kalman DS. Curcumin: A Review of Its Effects on Human Health. Foods.
Marton LT, et al. Curcumin and inflammatory diseases: Clinical evidence and molecular mechanisms. Frontiers in Pharmacology. 2021.
Pagano E, et al. Curcumin and intestinal barrier function: recent advances. Nutrients. 2023.

Lactobacillus acidophilus
Sanders ME, Merenstein DJ, Reid G, Gibson GR, Rastall RA. Probiotics and microbiota: scientific advances. Nature Reviews Gastroenterology & Hepatology.
Hill C, Guarner F, Reid G, et al. The International Scientific Association for Probiotics and Prebiotics (ISAPP): Consensus Statement on Probiotics.

Lactobacillus plantarum
Marco ML, et al. Health benefits of Lactobacillus plantarum: clinical update. Annual Review of Food Science and Technology. 2022.
Plaza-Diaz J, et al. Mechanisms of action of probiotics in gastrointestinal health. Nutrients. 2021.

Lactobacillus rhamnosus
Segers ME, Lebeer S. Towards a better understanding of Lactobacillus rhamnosus in human health. FEMS Microbiology Reviews.
Goldenberg JZ, et al. Probiotics for prevention of antibiotic-associated diarrhea. Cochrane Database of Systematic Reviews. Most recent update.

Saccharomyces boulardii
McFarland LV. Systematic review and meta-analysis of Saccharomyces boulardii in adult and pediatric gastrointestinal disorders. Clinical and Experimental Gastroenterology. Updates.
Kelesidis T, Pothoulakis C. Efficacy and safety of Saccharomyces boulardii: current evidence. Current Opinion in Gastroenterology.

Bacillus coagulans
Cao J, et al. Bacillus coagulans: characteristics, mechanisms and clinical applications. Beneficial Microbes.
Madempudi RS, et al. Clinical applications of Bacillus coagulans probiotics. Probiotics and Antimicrobial Proteins. 2022.

Intestinal microbiota and urogenital health
Brubaker L, Wolfe AJ. The female urinary microbiota, urinary tract infections and clinical implications. Nature Reviews Urology.
Neugent ML, Hulyalkar NV, Nguyen VH, Zimmern PE, De Nisco NJ. Advances in understanding urinary tract infections and the urinary microbiome. Nature Reviews Urology.
European Association of Urology. Guidelines on Urological Infections. 2025 update.

Regulations
Directive 2002/46/EC on food supplements.
Regulation (EC) No 178/2002.
Regulation (EC) No 1924/2006 on nutrition and health claims.
Regulation (EU) No 432/2012 on the list of authorized claims.
Regulation (EU) No 1169/2011 on the provision of food information to consumers.
Ministry of Health. Guidelines on probiotics and prebiotics. Latest available revision.
Ministerial Decree of 10 August 2018 and subsequent updates on substances and herbal preparations permitted in food supplements.

IMPORTANT WARNING In case of liver or biliary disorders or gallstones, use of the product is not recommended. Do not use during pregnancy or breastfeeding. Do not use for prolonged periods without consulting a doctor. If you are taking medication, it is advisable to consult your doctor. Do not take if you are allergic to any of its ingredients.
Food supplement. Keep out of reach of children. Do not exceed the recommended daily dose. Food supplements should not be used as a substitute for a varied and balanced diet and a healthy lifestyle. As with any supplement, it is important to consult your doctor or healthcare professional before use during pregnancy or breastfeeding, if you are taking medication, if you have any medical conditions or illnesses, or before any medical procedure. Discontinue use in case of adverse reactions and consult your doctor or healthcare professional.

The information provided in the product pages of this website is for informational and educational purposes only and does not constitute medical advice. The published content is not intended to replace consultation with a doctor or any medical advice, diagnosis, or prescriptions. The information provided describes the ingredients and characteristics of food supplements, which are intended to support the body’s balance and well-being as part of a healthy lifestyle. Food supplements are not medicines and must not be used to prevent, diagnose, treat, or alleviate diseases or medical conditions.